Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms
复制标题
怀孕和产后色氨酸代谢的变化：可能参与产后抑郁症状
DOI：
10.1016/j.jad.2019.05.028
复制
发表时间：
2019
影响因子：
6.6
通讯作者：
Saito Kuniaki
中科院分区：
文献类型：
--
作者：
Teshigawara Tomoaki;Mouri Akihiro;Kubo Hisako;Nakamura Yukako;Shiino Tomoko;Okada Takashi;Morikawa Mako;Nabeshima Toshitaka;Ozaki Norio;Yamamoto Yasuko;Saito Kuniaki
背景许多妇女在怀孕和产后期间会出现抑郁症状。这些抑郁症状通常伴随着怀孕期间出现的其他炎症性疾病。色氨酸（Tryptophan，TRP）代谢通过诱导炎症而影响抑郁症的发生，引起了人们的广泛关注。我们研究了TRP代谢产物在妊娠期间和/或产后period.MethodsIn与以前的分析使用爱丁堡产后抑郁量表（EPDS）的孕妇抑郁症状的血浆水平的变化，参与者被分为非抑郁（ND）组，产后抑郁症（PD）组，暂时妊娠抑郁症（TG）组，和连续抑郁症（CD）组。分别于分娩前和分娩后1个月采集血样。采用高效液相色谱法（HPLC）测定血浆TRP代谢产物的浓度。结果妊娠期和产后期间ND组和PD组血浆TRP代谢产物的浓度存在差异，而TG组和CD组无差异。在PD组中，妊娠期间犬尿氨酸（KYN）和犬尿烯酸（KA）的血浆水平以及KYN/TRP和KA/KYN比值高于ND组，产后期间3-羟基邻氨基苯甲酸（3 HAA）低于ND组。妊娠期KYN/TRP、KA/KYN比值及产后低水平的3 HAA可作为产后抑郁症状的预测和诊断指标。
BackgroundMany women experience depressive symptoms during pregnancy and postpartum periods. These depressive symptoms are often accompanied by other inflammatory morbidities present during pregnancy. Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation. We examined the changes in plasma levels of TRP metabolites in pregnant women with depressive symptoms during pregnancy and/or the postpartum period.MethodsIn line with a previous analysis using the Edinburgh Postnatal Depression Scale (EPDS), participants were divided into a non-depressive (ND) group, a postpartum depressive (PD) group, a temporary gestational depressive (TG) group, and a continuous depressive (CD) group. Blood samples were collected before and 1 month after delivery. The concentrations of plasma TRP metabolites were measured using high-performance liquid chromatography (HPLC).ResultsThere are differences in plasma levels of TRP metabolites during pregnancy and postpartum periods between the ND group and the PD group, but not the TG or CD group. In the PD group, plasma levels of kynurenine (KYN) and kynurenic acid (KA), and KYN/TRP and KA/KYN ratio during the pregnancy period were higher and 3-hydroxyanthranilic acid (3HAA) during the postpartum period was lower than those in the ND group.LimitationsHistories regarding mood disorders before pregnancy were not assessed.ConclusionsThe higher plasma levels of KYN and KA, and KYN/TRP and KA/KYN ratio during pregnancy period and lower plasma level of 3HAA during the postpartum period could be useful predictive and diagnostic markers of postpartum depressive symptoms.