Coagulation Disorders in COVID-19: Role of Toll-like Receptors.
Coagulation Disorders in COVID-19: Role of Toll-like Receptors.
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DOI：
10.2147/jir.s271768
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发表时间：
2020
影响因子：
4.5
通讯作者：
Khan GA
中科院分区：
文献类型：
--
作者：
Biswas I;Khan GA
冠状病毒病2019(新冠肺炎)在全球迅速传播。这种疾病的范围很广，但住院的新冠肺炎患者中有凝血障碍、肺炎、呼吸衰竭和急性呼吸窘迫综合征。早期反应促炎细胞因子的过度产生导致了被描述为细胞因子风暴，导致血栓形成、炎症、血管高通透性、多器官衰竭的风险增加，最终随着时间的推移而死亡。由于疫情正在蔓延，整体情况尚不明朗，我们强调了新冠肺炎感染人群中凝血功能紊乱的重要性，并进行了总结。新冠肺炎感染可导致凝血功能紊乱，导致血栓形成和肺栓塞，对患者的康复和生存造成不利影响。凝血与炎症密切相关。在这篇综述中，我们试图建立与先天性免疫激活、炎症和凝血激活相关的病毒感染之间的联系。
Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.