The vitals of NETs.
The vitals of NETs.
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DOI：
10.1002/jlb.3ru0620-375r
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发表时间：
2021-10
影响因子：
5.5
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中科院分区：
文献类型：
--
作者：
中性粒细胞通过排出嵌入有瓜氨酸组蛋白 H3、髓过氧化物酶和其他细胞内分子的细胞外染色质来产生中性粒细胞胞外陷阱 (NET)。自 2004 年发现以来，大量文章证明了 NET 的形成机制及其在先天免疫和炎症中的功能。 NET 成分通常发挥抗菌作用，但过量的 NET 是有害的，会导致炎症和组织损伤。这篇综述强调了在识别 NET 形成的新途径和机制方面的最新进展。我们还关注 NET 对单个器官的具体破坏性影响。然后我们讨论各种 NET 检测方法的进展和局限性。总的来说，NET 的这些重要方面显着提高了我们对 NET 病理学的理解，以及未来用于检查和调节炎症性疾病中 NET 的诊断和治疗工具。
Neutrophils produce neutrophil extracellular traps (NETs) by expelling their extracellular chromatin embedded with citrullinated histone H3, myeloperoxidase, and other intracellular molecules. Since their discovery in 2004, numerous articles have demonstrated the mechanism of NET formation and their function in innate immunity and inflammation. NET components often play an antimicrobial role, but excessive NETs are deleterious and can cause inflammation and tissue damage. This review highlights recent advancements in the identification of novel pathways and mechanisms of NET formation. We also focus on the specific damaging impact of NETs in individual organs. We then discuss the progress and limitations of various NET detection assays. Collectively, these vital aspects of NETs significantly improve our understanding of the pathobiology of NETs and future diagnostics and therapeutic tools for examining and modulating NETs in inflammatory diseases.