Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels
Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels
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DOI：
10.3233/jad-121906
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发表时间：
2013-01-01
影响因子：
4
通讯作者：
Bartres-Faz, David
中科院分区：
文献类型：
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作者：
Arenaza-Urquijo, Eider M.;Molinuevo, Jose-Luis;Bartres-Faz, David
认知储备能力可能增加神经退行性过程的耐受性。然而，其在认知正常受试者中淀粉样蛋白- β (A β(42))沉积中的作用尚不清楚。我们的目的是研究在A β(42)脑脊液（CSF）浓度正常或异常的认知完整受试者中显示A β(42)相关结构改变的区域与认知储备代理之间的关系。33名受试者（55-85岁）接受腰椎穿刺和高分辨率解剖磁共振成像，通过基于体素的形态测量和皮质厚度程序进行分析。与A β (42) CSF水平正常的受试者相比，A β (42) CSF水平异常的受试者表现出明显的左侧海马萎缩，顶叶、颞叶和额叶区域（包括边缘上和前扣带回）皮质变薄。使用多元一般线性模型，我们研究了这些区域与认知储备代理之间的关系。我们发现，只有在a β(42)脑脊液水平异常的组中，左侧海马体积减少或右侧边缘上回皮质厚度减少与认知储备指标升高之间存在显著关系。因此，A β (42) CSF水平异常的受试者（患阿尔茨海默病的风险可能更高）和认知储备代理评分较高的受试者可能在关键的皮层和皮层下区域耐受更晚期的神经退行性过程。目前的结果强调了评估认知储备代理的相关性，以及在具有较高储备的个体中使用神经影像学技术进行早期诊断的重要性。
Cognitive reserve capacity may increase tolerance of neurodegenerative processes. However, its role regarding amyloid-beta (A beta(42)) deposition in cognitively normal subjects is not well understood. We aimed to investigate the association between areas showing A beta(42)- related structural changes and cognitive reserve proxies in cognitively intact subjects showing normal or abnormal A beta(42) cerebrospinal fluid (CSF) concentrations. Thirty-three subjects (aged 55-85) underwent lumbar puncture and high resolution anatomical magnetic resonance imaging analyzed by voxel-based morphometry and cortical thickness procedures. Subjects with abnormal A beta(42) CSF levels showed significant left hippocampal atrophy and greater cortical thinning in parietal, temporal, and frontal regions (including the supramarginal and the anterior cingulate gyrus) compared to subjects with normal A beta(42) CSF levels. Using a multivariate general linear model, we investigated the relationship between these areas and cognitive reserve proxies. We found a significant relationship between decreased volume of the left hippocampus or decreased cortical thickness of the right supramarginal gyrus and higher cognitive reserve proxies only in the group with abnormal A beta(42) CSF levels. Thus, subjects with abnormal A beta(42) CSF levels (which may be at a higher risk of developing Alzheimer's disease) and with high scores on cognitive reserve proxies may be tolerating a more advanced neurodegenerative process in critical cortical and subcortical regions. The present results emphasize the relevance of evaluating cognitive reserve proxies, as well as the importance of using neuroimaging techniques for early diagnosis in individuals with higher reserve.