Mortality Rates and Age at Death from Sickle Cell Disease: US, 1979-2005
Mortality Rates and Age at Death from Sickle Cell Disease: US, 1979-2005
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DOI：
10.1177/003335491312800206
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发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Haywood, Carlton, Jr.
中科院分区：
文献类型：
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作者：
Lanzkron, Sophie;Carroll, C. Patrick;Haywood, Carlton, Jr.
目标.在过去的30年里，镰状细胞病（SCD）儿童的生存率得到了很好的改善。对于患有这种疾病的成年人是否有类似的改善尚不清楚。我们调查了SCD儿童和成人的死亡率。我们使用国家卫生统计中心的多死因文件来检查死亡年龄，并计算1979年至2005年的死亡率。我们使用负二项回归分析了死亡率的趋势，使用t检验和线性回归分析了死亡年龄。我们确定了16，654例镰状细胞相关死亡。男性（33.4岁，95%置信区间[CI] 33.0，33.7）与女性（36.9岁，95% CI 36.5，37.4）的平均死亡年龄存在显著差异。在一个控制性别的回归模型中，平均死亡年龄在研究的每一年增加0.36岁。2005年，女性的死亡年龄中位数为42岁，男性为38岁。总死亡率增加0.7%（p19岁）死亡率增加1%（p
Objectives. Improvements in survival for children with sickle cell disease (SCD) during the last 30 years have been well established. Whether similar improvements for adults with the disease have occurred is unknown. We investigated mortality rates for children and adults with SCD.Methods. We used the National Center for Health Statistics multiple-cause-of-death files to examine age at death and calculate mortality rates from 1979 to 2005. We examined trends in mortality rates using negative binomial regression, and we examined age at death using t-tests and linear regression.Results. We identified 16,654 sickle cell-related deaths. Mean age at death was significantly different for males (33.4 years, 95% confidence interval [CI] 33.0, 33.7) than for females (36.9 years, 95% CI 36.5, 37.4). In a regression model controlling for gender, the mean age at death increased by 0.36 years for each year of the study. The median age at death in 2005 was 42 years for females and 38 years for males. The overall mortality rate increased 0.7% (p19 years of age) mortality rate increased by 1% (p