Interplay of ryanodine receptor distribution and calcium dynamics
Interplay of ryanodine receptor distribution and calcium dynamics
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DOI：
10.1529/biophysj.105.077214
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Balke, C. William
中科院分区：
文献类型：
--
作者：
Izu, Leighton T.;Means, Shawn A.;Balke, C. William
自发产生的钙（Ca2+）波可在心室和心房肌细胞中引发心律失常。然而，Ca2+波也具有介导心房肌细胞中整体Ca2+增加和肌肉收缩的生理功能。我们通过数学建模和大规模计算（超级计算机）模拟来研究影响Ca2+波起始的因素。一个重要发现是兰尼碱受体分布与Ca2+动力学之间存在强耦合。兰尼碱受体间距即使是适度的改变也会深刻影响Ca2+波起始的概率。基于这一发现，我们认为从收缩系统到Ca2+控制系统存在信息流，这种动态相互作用可能导致心力衰竭期间心律失常发生率增加。
Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.