Proximity to a Major Road and Plasma Cytokines in School-Aged Children.
Proximity to a Major Road and Plasma Cytokines in School-Aged Children.
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DOI：
10.1089/ped.2016.0649
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发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Celedón JC
中科院分区：
文献类型：
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作者：
Rosser F;Forno E;Brehm J;Han YY;Boutaoui N;Colón-Semidey A;Alvarez M;Acosta-Pérez E;Kurland KS;Alcorn JF;Canino G;Celedón JC
空气污染（TRAP）可能会影响免疫反应，包括TH 2和TH 17途径。为了检测TRAP是否与哮喘儿童和非哮喘儿童的血浆TH 17-、TH 1-和TH 2-相关细胞因子水平相关，对圣胡安（波多黎各）的577名哮喘儿童（年龄6-14岁）（n = 294）和非哮喘儿童（n = 283）进行了横断面研究。使用研究参与者的地理编码家庭地址估计住宅到主要道路的距离。在血浆中测量一组14种细胞因子，富集TH 17途径。哮喘定义为医生诊断的哮喘和当前的喘息。多变量线性回归用于研究住宅距离主要道路（一个标记的TRAP），哮喘，细胞因子水平的关联。在所有参与研究的儿童中，住宅区靠近主要道路与IL-31血浆水平升高显著相关，即使在调整相关协变量和校正多重检测后也是如此。哮喘的存在改变了居住地到主要道路的距离对血浆TNF-α的估计影响（相互作用P = 0.00047）。虽然在对照组中，远离主干道的生活与较低的TNF-α水平显著相关，但在哮喘儿童中没有观察到这种下降。在病例组和对照组的直接比较中，哮喘儿童的IL-1β、IL-22和IL-33水平显著高于对照组。TRAP与波多黎各儿童中促炎细胞因子水平升高相关，这些儿童属于哮喘高风险的种族群体。
Traffic-related air pollution (TRAP) may affect immune responses, including those in the TH2 and TH17 pathways. To examine whether TRAP is associated with plasma level of TH17-, TH1-, and TH2-related cytokines in children with and without asthma, a cross-sectional study of 577 children (ages 6–14 years) with (n = 294) and without (n = 283) asthma in San Juan (Puerto Rico) was performed. Residential distance to a major road was estimated using geocoded home addresses for study participants. A panel of 14 cytokines, enriched for the TH17 pathway, was measured in plasma. Asthma was defined as physician-diagnosed asthma and current wheeze. Multivariable linear regression was used to examine the association of residential distance to a major road (a marker of TRAP), asthma, and cytokine levels. Among all participating children, residential proximity to a major road was significantly associated with increased plasma level of IL-31, even after adjustment for relevant covariates and correction for multiple testing. The presence of asthma modified the estimated effect of the residential distance to a major road on plasma TNF-α (P for interaction = 0.00047). Although living farther from a major road was significantly associated with lower TNF-α level in control subjects, no such decrease was seen in children with asthma. In a direct comparison of cases and control subjects, children with asthma had significantly higher levels of IL-1β, IL-22, and IL-33 than control subjects. TRAP is associated with increased levels of proinflammatory cytokines among Puerto Rican children, who belong to an ethnic group with high risk for asthma.