Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies
Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies
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DOI：
10.1016/j.ijheh.2013.09.006
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发表时间：
2014-04-01
影响因子：
6
通讯作者：
Heinrich, Joachim
中科院分区：
文献类型：
--
作者：
Liu, Chuang;Flexeder, Claudia;Heinrich, Joachim
以前的大多数研究都是在哮喘儿童中进行的，这些研究调查了空气污染对呼吸道炎症的短期影响，通过呼出的一氧化氮(ENO)的增加来评估。很少有研究认为非哮喘患者之间存在这种潜在的联系。此外，尽管空气污染对ENO的短期和长期影响都有单独报道，但包括两者的研究很少。我们利用慕尼黑和威塞尔两个德国出生队列的数据，研究了1985名10岁儿童(192名哮喘患者和1793名非哮喘儿童)24小时NO2和PM10(空气动力学直径小于10微米的颗粒物)质量与eNO的关系，并通过调整NO2、PK10质量、PM2.5质量(空气动力学直径小于2.5微米的颗粒物)和PM2.5吸光度的年平均值来考虑空气污染的长期影响。总体而言，在单污染物模型(百分比变化量：18.30%，95%可信区间：11.63-25.37)和双污染物模型(14.62%，6.71-23.11)中，24小时NO2和ENO之间都观察到了很好的相关性。24 h PM10质量与ENO的相关性仅在单污染物模型中显著(9.59%，4.80-14.61)。在非哮喘儿童中也观察到了同样的显著关联，而在哮喘儿童中它们没有达到显著水平。环境空气污染的年平均值(NO2、PM10质量、PM2.5质量和PM2.5吸光度)与ENO之间的关联始终为零。总而言之，短期环境空气污染与ENO之间存在显著的正相关。本研究未发现空气污染对ENO的长期影响。(C)2013年爱思唯尔股份有限公司。版权所有。
Most previous studies which have investigated the short-term effects of air pollution on airway inflammation, assessed by an increase of exhaled nitric oxide (eNO), have been conducted among asthmatic children. Few studies have considered this potential association among non-asthmatics. Furthermore, although both short- and long-term effects of air pollution on eNO had been reported separately, studies which include both are scarce. We explored associations between 24h NO2 and PM10 (particles with aerodynamic diameters below 10 mu m) mass with eNO in 1985 children (192 asthmatics and 1793 non-asthmatics) aged 10 years and accounted for the long-term effects of air pollution by adjusting for annual averages of NO2, PK10 mass, PM2.5 mass (particles with aerodynamic diameters below 2.5 mu m) and PM2.5 absorbance, using data from two German birth cohorts in Munich and Wesel. In total, robust associations between 24h NO2 and eNO were observed in both single-pollutant (percentage change: 18.30%, 95% confidence interval: 11.63-25.37) and two-pollutant models (14.62%, 6.71-23.11). The association between 24 h PM10 mass and eNO was only significant in the single-pollutant model (9.59%, 4.80-14.61). The same significant associations were also observed in non-asthmatic children, while they did not reach significant levels in asthmatic children. Associations between annual averages of ambient air pollution (NO2, PM10 mass, PM2.5 mass and PM2.5 absorbance) and eNO were consistently null. In conclusion, significantly positive associations were observed between short-term ambient air pollution and eNO. No long-term effects of air pollution on eNO were found in this study. (C) 2013 Elsevier GmbH. All rights reserved.