Comparison of Plasma Glucose and Gut Hormone Levels Between Drinking Enteral Formula Over a Period of 5 and 20 Minutes in Japanese Patients With Type 2 Diabetes: A Pilot Study.
Comparison of Plasma Glucose and Gut Hormone Levels Between Drinking Enteral Formula Over a Period of 5 and 20 Minutes in Japanese Patients With Type 2 Diabetes: A Pilot Study.
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DOI：
10.14740/jocmr2686w
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Terauchi Y
中科院分区：
文献类型：
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作者：
Kamiko K;Aoki K;Kamiyama H;Taguri M;Terauchi Y
据报道，进食速度过快与肥胖、脂肪肝和代谢综合征有关。由于此前尚未报道过日本 2 型糖尿病患者快速或缓慢进食后餐后血糖水平的比较，因此我们评估了快速或缓慢摄入肠内配方食品（流质餐）对葡萄糖代谢的影响。纳入曾在我院住院的日本2型糖尿病患者10例。所有受试者早餐均接受肠内配方奶粉。该研究对每位受试者进行为期 2 天的研究（第 1 天：在 5 分钟内食用肠内配方奶粉；第 2 天：在 20 分钟内食用肠内配方奶粉）。要求受试者在吃早餐前禁食至少12小时，并在早餐开始后0、30、60和120分钟采集血样。血浆葡萄糖、血清胰岛素、血浆活性生长素释放肽、胰高血糖素样肽-1 (GLP-1)、血浆总葡萄糖依赖性促胰岛素多肽 (GIP) 和血清总肽 YY (PYY) 水平的曲线下面积 (AUC) 在 5 分钟或 20 分钟内没有因摄入而发生显着变化。快速进食本身可能不会影响餐后血糖波动，但快速进食导致的能量摄入增加可能会增加体重并增加胰岛素抵抗。吃得快可能会增加能量摄入并恶化长期代谢参数。
A fast eating speed is reportedly associated with obesity, fatty liver, and metabolic syndrome. As a comparison of postprandial glucose levels after eating quickly or slowly has not been previously reported for Japanese patients with type 2 diabetes, we evaluated the impact of the fast or slow ingestion of an enteral formula (liquid meal) on glucose metabolism. Ten Japanese patients with type 2 diabetes who had been hospitalized at our hospital were enrolled. All the subjects received an enteral formula for breakfast. The study was performed over a 2-day period in each subject (day 1: enteral formula was consumed over a 5-minute period; day 2: enteral formula was consumed over a 20-minute period). The subjects were requested to fast for at least 12 hours before eating breakfast, and blood samples were collected at 0, 30, 60, and 120 min after the start of breakfast. The areas under the curve (AUCs) of the plasma glucose, serum insulin, plasma active ghrelin, glucagon-like peptide-1 (GLP-1), plasma total glucose-dependent insulinotropic polypeptide (GIP), and serum total peptide YY (PYY) levels were not significantly changed by intake over a 5-minute or 20-minute period. Eating quickly per se probably does not affect postprandial glucose excursions, but the increased energy intake resulting from eating quickly may increase the body weight and increase insulin resistance. Eating quickly may increase energy intake and worsen long-term metabolic parameters.