Influence of Cell Cycle Phase on Apparent Diffusion Coefficient in Synchronized Cells Detected Using Temporal Diffusion Spectroscopy
Influence of Cell Cycle Phase on Apparent Diffusion Coefficient in Synchronized Cells Detected Using Temporal Diffusion Spectroscopy
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DOI：
10.1002/mrm.22704
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发表时间：
2011-04-01
影响因子：
3.3
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Xu, Junzhong;Xie, Jingping;Gore, John C.
MR方法测量的组织水表观扩散系数与细胞生理状态之间的关系对于更好地理解和解释扩散加权MRI具有特殊的相关性。此外，人们对开发能够提供组织微观结构（包括细胞内变化）新信息的扩散依赖成像方法非常感兴趣。为此，传统的脉冲梯度自旋回波法和探测极短距离扩散的振荡梯度自旋回波法(
The relationship between the apparent diffusion coefficient of tissue water measured by MR methods and the physiological status of cells is of particular relevance for better understanding and interpretation of diffusion-weighted MRI. In addition, there is considerable interest in developing diffusion-dependent imaging methods capable of providing novel information on tissue microstructure, including intracellular changes. To this end, both the conventional pulsed gradient spin-echo methods and the oscillating gradient spin-echo method, which probes diffusion over very short distance (