Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance.
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance.
复制标题
DOI：
10.1016/j.cmet.2012.06.015
复制
发表时间：
2012-09-05
期刊：
影响因子：
29
通讯作者：
Hayes MR
中科院分区：
文献类型：
--
作者：
Grill HJ;Hayes MR
本文综述了中脑核团的信息加工和整合，重点介绍孤束核（NTS）神经元接受的信息输入。这些输入包括迷走神经介导的胃肠道饱足信号、血液能量相关的激素和营养信号以及来自前脑的下行神经信号。我们建议，NTS（和更广泛的后脑神经元）整合这些多个能量状态信号，并发出输出命令，控制行为，自主神经和内分泌反应，共同管理能量平衡。这些后脑介导的控制是神经解剖学分布的，它们涉及地方性后脑神经元和回路，后脑投射到外周回路，以及投射到中脑和前脑核团。
This review highlights the processing and integration performed by hindbrain nuclei, focusing on the inputs received by nucleus tractus solitarius (NTS) neurons. These inputs include vagally-mediated gastrointestinal satiation signals, blood-borne energy-related hormonal and nutrient signals, and descending neural signals from the forebrain. We propose that NTS (and hindbrain neurons more broadly) integrate these multiple energy status signals and issue output commands controlling the behavioral, autonomic, and endocrine responses that collectively govern energy balance. These hindbrain-mediated controls are neuroanatomically distributed; they involve endemic hindbrain neurons and circuits, hindbrain projections to peripheral circuits, and projections to and from midbrain and forebrain nuclei.