A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects
A Study of Association of Ankle Brachial Index (ABI) and the Highly Sensitive C - Reactive Protein (hsCRP) in Type 2 Diabetic Patients and in Normal Subjects
复制标题
DOI：
10.7860/jcdr/2012/4854.2667
复制
发表时间：
2013-01-01
影响因子：
0.2
通讯作者：
Kumar, Prasanna K. M.
中科院分区：
文献类型：
--
作者：
Thwaswini, K. O.;Roopakala, M. S.;Kumar, Prasanna K. M.
背景：踝臂指数（ABI）客观评价下肢动脉灌注。低ABI提示动脉粥样硬化和外周动脉疾病（PAD）。PAD在2型糖尿病（2型DM）患者中更常见。炎症标志物被发现与2型糖尿病相关。目的：比较2型糖尿病患者和正常人的ABI和hsCRP水平，探讨2型糖尿病患者和正常人血清hsCRP水平与ABI的关系。研究对象为40例2型糖尿病患者和40例年龄、性别、BMI匹配的正常人，年龄在45-60岁之间，分为两组。第1组为2型糖尿病患者，第2组为健康对照组。采用比浊法（BIOSYSTEMS）测定血清hsCRP水平，采用尼科莱VERSALAB常规连续波（CW）多普勒测定ABI值。统计学分析：采用Student's t检验（双尾;独立）分析两组研究参数的显著性。结果：2型糖尿病患者ABI明显低于正常对照组（P=0.035*），hsCRP有明显升高趋势（P = 0.069+）。2型DM患者ABI与hsCRP呈负相关（r=-0.560，p
Background: The Ankle-Brachial Index (ABI) objectively assesses the lower extremity arterial perfusion. A low ABI suggests atherosclerosis and Peripheral Arterial Disease (PAD). PAD is more common in individuals with type2 Diabetes mellitus (Type2 DM). Inflammatory markers are found to be associated with Type2 DM. But the association of the inflammatory markers with the atherosclerotic burden remains poorly defined.Aims: To compare the ABI and the hsCRP in the Type 2 DM patients with those in the normal subjects and to study the association of serum hsCRP with ABI in the Type 2 DM patients and in normal subjects.Methods: The subjects were 40 Type2 DM and 40 age, sex and BMI matched normal subjects who were aged between 45-60 yrs. The subjects were assigned to two different groups. Groupl- the Type2 DM patients and Group2- the healthy controls. The serum hsCRP levels were determined by the turbidimetry method (BIOSYSTEMS) and the ABI values were deter- mined by using the traditional continuous wave (CW) Doppler of NICOLET VERSALAB.Statistical Analysis: The data was analyzed by using the Student's t test (two tailed; independent) to find the significance of the study parameters between the two groups. Pearson's Correlation was used to find the correlation of serum hsCRP with the ABI in the two groups.Results: The ABI showed a significantly low value (P=0.035*) and the serum hsCRP showed a trend towards a significant increase (p = 0.069+) in the type2diabetics as compared to those in the normals. There was a significant negative correlation between ABI and hsCRP in the Type 2 DM patients (r=-0.560, p