DOSE REQUIREMENTS OF ICI 35,868 (PROPOFOL, DIPRIVAN) IN A NEW FORMULATION FOR INDUCTION OF ANESTHESIA
DOSE REQUIREMENTS OF ICI 35,868 (PROPOFOL, DIPRIVAN) IN A NEW FORMULATION FOR INDUCTION OF ANESTHESIA
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DOI：
10.1111/j.1365-2044.1984.tb06425.x
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发表时间：
1984-01-01
期刊：
影响因子：
10.7
通讯作者：
STEPHENSON, DK
中科院分区：
文献类型：
--
作者：
CUMMINGS, GC;DIXON, J;STEPHENSON, DK
为了避免Cremophor相关反应并降低注射疼痛的发生率，将二异丙基苯酚（ICI 35，868;丙泊酚）重新配制为乳剂。115例患者接受了新制剂中丙泊酚的诱导剂量。在95%的健康、未预先用药患者中诱导麻醉所需的剂量为2.5 mg/kg。诱导与一定程度的心血管和呼吸抑制有关。虽然有一些轻微的副作用，但没有不良反应。注射时疼痛的发生率较低（3%），92%的患者的总体诱导质量被评估为良好或足够。
In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.