Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute
Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute
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DOI：
10.1016/j.ceramint.2021.09.260
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发表时间：
2021-11-29
影响因子：
5.2
通讯作者：
Miyamoto, Youji
中科院分区：
文献类型：
--
作者：
Fukuda, Naoyuki;Ishikawa, Kunio;Miyamoto, Youji
颗粒状碳酸盐磷灰石(CO3Ap)骨替代材料具有较高的骨传导性，可被新骨替代，临床效果良好，尤其是在骨强化手术中。本研究旨在评价CO3Ap骨替代物在Beagle犬术后9周随访期内保存牙槽骨的应用价值。术后4周和9周，CO3Ap颗粒(CO3Ap组)重建拔牙槽的牙槽骨高度比有血块的(对照组)高约1.0 mm。此外，在术后4周和9周，CO3Ap组牙槽骨颊侧面的测量面积比对照组大约2mm2。牙槽骨颊侧至腭侧的连续性得到恢复，术后4周仍保持其轮廓。术后9周，尽管未见CO3Ap颗粒完全被新骨替代，但牙槽骨部分的骨组织数量，尤其是成熟骨的数量，仍明显多于对照组。综上所述，CO3Ap颗粒具有良好的保存牙槽骨的潜力。
Granular-shaped carbonate apatite (CO3Ap) bone substitute has demonstrated good clinical results, especially in the bone augmentation procedure, because it has high osteoconductivity and can be replaced by a new bone. This study aimed to evaluate the potential usefulness of CO3Ap bone substitute for alveolar ridge preservation of beagle dogs during the 9-week follow-up period after surgery. Reconstruction of extraction sockets with CO3Ap granules (CO3Ap group) allowed approximately 1.0 mm higher alveolar bone height than that with a blood clot (control group) at 4 and 9 weeks after surgery. Additionally, the measured area at the buccal aspect of the alveolar bone in the CO3Ap group was approximately 2 mm2 larger than that in the control group at 4 and 9 weeks after surgery. Continuity from the buccal side to palatal side of the alveolar bone was restored, maintaining its contour at 4 weeks after surgery. The amount of bony tissue, especially the amount of mature bone, in the alveolar part was statistically larger than that of control group at 9 weeks after surgery even though complete replacement of CO3Ap granules with new bone was not observed within 9 weeks. In conclusion, CO3Ap granules have good potential for alveolar ridge preservation.