The role of epidermal sphingolipids in dermatologic diseases.
The role of epidermal sphingolipids in dermatologic diseases.
复制标题
DOI：
10.1186/s12944-016-0178-7
复制
发表时间：
2016-01-19
影响因子：
4.5
通讯作者：
Cudnoch-Jedrzejewska A
中科院分区：
文献类型：
--
作者：
Borodzicz S;Rudnicka L;Mirowska-Guzel D;Cudnoch-Jedrzejewska A
鞘脂是一组含有鞘氨醇碱的脂质，在人体表皮中具有结构和生物学功能。神经酰胺作为角质层细胞外脂质的一部分，是皮肤屏障的重要成分，并参与预防经表皮水分流失。此外，神经酰胺调节角质形成细胞的增殖、分化和凋亡等过程。另一种重要的鞘脂，鞘氨醇-1-磷酸（S1 P），抑制角质形成细胞的增殖和诱导分化。最近一项关于ponesimod（S1 P受体1的选择性调节剂）的疗效和安全性的临床研究表明，鞘脂代谢可能成为银屑病药物治疗的新靶点。本文就鞘脂在银屑病、特应性皮炎、鱼鳞病等皮肤病中的作用作一综述。
Sphingolipids, a group of lipids containing the sphingoid base, have both structural and biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the stratum corneum, are important elements of the skin barrier and are involved in the prevention of transepidermal water loss. In addition, ceramides regulate such processes as proliferation, differentiation and apoptosis of keratinocytes. Another important sphingolipid, sphingosine-1-phosphate (S1P), inhibits proliferation and induces differentiation of keratinocytes. A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis. The role of sphingolipids in some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses was summarized in this article.