CHRONIC ETHANOL EXPOSURE POTENTIATES THE LOCOMOTOR-ACTIVATING EFFECTS OF CORTICOTROPIN-RELEASING FACTOR (CRF) IN RATS
CHRONIC ETHANOL EXPOSURE POTENTIATES THE LOCOMOTOR-ACTIVATING EFFECTS OF CORTICOTROPIN-RELEASING FACTOR (CRF) IN RATS
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DOI：
10.1016/0167-0115(87)90176-5
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发表时间：
1987-12-01
影响因子：
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通讯作者：
CHAPLIN, RI
中科院分区：
文献类型：
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作者：
EHLERS, CL;CHAPLIN, RI
在雄性 Wistar 大鼠中研究了长期接触乙醇蒸气（21 天）对脑室内（i.c.v.）注射促肾上腺皮质激素释放因子（CRF）的运动反应的影响。在长期暴露期间、去除乙醇蒸气后 1 1/2 小时以及去除乙醇后两周测试对 CRF 的反应。在乙醇暴露期间（P < 0.001）和去除乙醇蒸气后 90 分钟（P < 0.001）但在停药后两周内，乙醇治疗的大鼠与对照组相比，对 CRF 的运动激活作用具有更高的敏感性。这些结果支持酒精中毒时下丘脑-垂体-肾上腺（HPA）轴可逆激活的临床发现。此外，长期接触乙醇似乎还可以改变对 CRF 运动激活作用特别敏感的中枢神经系统。
The effects of chronic exposure (21 days) to ethanol vapors on locomotor response to intracerebroventricular (i.c.v.) adminsitration of corticotropin releasing factor (CRF) was investigated in male Wistar rats. Responses to CRF were tested during chronic exposure, 1 1/2 hours following removal of ethanol vapors, and two weeks after withdrawal of ethanol. A greater sensitivity to the locomotor-activating effects of CRF was found in ethanol-treated rats as compared to their controls during ethanol exposure (P < 0.001) and 90 min following removal of ethanol vapors (P < 0.001) but not two weeks following withdrawal. These results support clinical findings of a reversible activation in the hypothalamic-pituitary-adrenal (HPA) axis in alcoholism. In addition, it appears that chronic exposure to ethanol can also modify central neuronal systems specifically responsive to the locomotor activating effects of CRF.