Apparent diffusion coefficient in vasogenic edema and reactive astrogliosis
Apparent diffusion coefficient in vasogenic edema and reactive astrogliosis
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DOI：
10.1007/s00234-007-0272-7
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发表时间：
2007-11-01
期刊：
影响因子：
2.8
通讯作者：
Reiche, Werner
中科院分区：
文献类型：
--
作者：
Hagen, Thomas;Ahlhelm, Frank;Reiche, Werner
在某些情况下，区分血管源性水肿和反应性星形胶质细胞增生可能是困难的。本研究进行测试的假设，扩散加权（DW）成像与表观扩散系数（ADC）地图可以用来区分这两种类型的changes.Methods研究人群包括11例患者与病变周围血管源性水肿和11例胶质增生检查与常规MR成像和DW成像。常规脉冲序列的信号强度和ADC值被计算在高信号水肿或胶质化区域的感兴趣区域，并与正常出现的白色物质进行比较。采用Mann-Whitney U检验比较胶质增生和血管源性水肿的信号强度比和ADC值。结果虽然常规MR图像上的信号强度比存在相当大的重叠，但胶质增生区域显示出显著较高的ADC值结论ADC值有助于反应性胶质增生与血管源性水肿的鉴别。
Introduction Distinguishing between vasogenic edema and reactive astrogliosis may be difficult in some instances. This study was performed to test the hypothesis that diffusion-weighted (DW) imaging with apparent diffusion coefficient (ADC) maps can be used to differentiate these two types of changes.Methods The study population included 11 patients with perilesional vasogenic edema and 11 patients with gliosis examined with conventional MR imaging and DW imaging. The signal intensities of conventional pulse sequences and ADC values were calculated in regions of interest placed in the hyperintense edematous or gliotic regions and compared with those of normal-appearing white matter. Signal intensity ratios and ADC values in gliosis were compared with those in vasogenic edema using the Mann-Whitney U-test.Results While considerable overlap was present for signal intensity ratios on conventional MR images, areas of gliosis demonstrated significantly higher ADC values (1.76+/-0.09x10(-3) mm2/s) than areas of vasogenic edema (1.35+/-0.06x10-3 mm(2)/s; P < 0.0001) without overlap.Conclusion ADC values are helpful in differentiating reactive gliosis from vasogenic edema.