Noradrenergic modulation of space exploration in visual neglect
Noradrenergic modulation of space exploration in visual neglect
复制标题
DOI：
10.1002/ana.20701
复制
发表时间：
2006-01-01
影响因子：
11.2
通讯作者：
Husain, M
中科院分区：
文献类型：
--
作者：
Malhotra, PA;Parton, AD;Husain, M
中风后的视觉忽视通常与未能探索病灶对侧空间有关。在这里，我们表明，胍法辛，去甲肾上腺素能激动剂，调节背外侧前额叶皮层，改善脑空间探索在选定的右半球忽视患者。胍法辛的积极影响与延长的能力，以保持注意力的任务。结果表明，神经药理学靶向完整的额叶区域可能是一种方法，以增强后脑区域损伤后的认知功能在选定的个人。
Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals.