HemOnc: A new standard vocabulary for chemotherapy regimen representation in the OMOP common data model
HemOnc: A new standard vocabulary for chemotherapy regimen representation in the OMOP common data model
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DOI：
10.1016/j.jbi.2019.103239
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发表时间：
2019-08-01
影响因子：
4.5
通讯作者：
Yang, Peter C.
中科院分区：
文献类型：
--
作者：
Warner, Jeremy L.;Dymshyts, Dmitry;Yang, Peter C.
系统应用观察数据来理解癌症治疗的影响需要详细的信息模型，以便在治疗方案之间进行有意义的比较。不幸的是，系统性治疗的细节在登记和数据仓库中很少，主要是由于协议的复杂性和缺乏标准化。自2011年以来，我们一直在创建一个关于化疗方案的策划和半结构化网站HemOnc.org。在与观察性健康数据科学和信息学（OHDSI）肿瘤学小组的协调下，我们已经将这些内容的大量子集转换为OMOP通用数据模型，并绑定到多个外部词汇表，例如，RxNorm和国家癌症研究所同义词词典。目前，在完整的词汇表中有> 73，000个概念和> 177，000个关系。与化疗方案的定义和组成相关的内容已在ATHENA工具（athena.ohdsi.org）中发布，供OHDSI成员广泛使用。在这里，我们描述了HemOnc词汇表的基本原理、数据模型和初始内容沿着它可能有价值的几个用例。
Systematic application of observational data to the understanding of impacts of cancer treatments requires detailed information models allowing meaningful comparisons between treatment regimens. Unfortunately, details of systemic therapies are scarce in registries and data warehouses, primarily due to the complex nature of the protocols and a lack of standardization. Since 2011, we have been creating a curated and semi-structured website of chemotherapy regimens, HemOnc.org. In coordination with the Observational Health Data Sciences and Informatics (OHDSI) Oncology Subgroup, we have transformed a substantial subset of this content into the OMOP common data model, with bindings to multiple external vocabularies, e.g., RxNorm and the National Cancer Institute Thesaurus. Currently, there are > 73,000 concepts and > 177,000 relationships in the full vocabulary. Content related to the definition and composition of chemotherapy regimens has been released within the ATHENA tool (athena.ohdsi.org) for widespread utilization by the OHDSI membership. Here, we describe the rationale, data model, and initial contents of the HemOnc vocabulary along with several use cases for which it may be valuable.