Poultry and Fish Consumption in Relation to Total Cancer Mortality: A Meta-Analysis of Prospective Studies
Poultry and Fish Consumption in Relation to Total Cancer Mortality: A Meta-Analysis of Prospective Studies
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DOI：
10.1080/01635581.2018.1412474
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发表时间：
2018-02
期刊：
影响因子：
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通讯作者：
Zheng Zhang;Guo-Chong Chen;Zhi-Zhen Qin;X. Tong;Da-Peng Li;L. Qin
中科院分区：
文献类型：
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作者：
Zheng Zhang;Guo-Chong Chen;Zhi-Zhen Qin;X. Tong;Da-Peng Li;L. Qin
关于鱼和家禽摄入量与癌症总死亡率风险之间关系的观察性研究报告结果不一。因此，我们旨在通过前瞻性研究的荟萃分析来评估这种关联。我们对PubMed数据库进行了文献检索，直至2017年2月1日，以确定相关的前瞻性研究。随机效应模型用于计算汇总估计。我们确定了14项前瞻性研究，涉及2,378,204名参与者和96,712例癌症死亡事件。鱼类（10项研究）和家禽（8项研究）的总癌症死亡率的合并相对危险度（RR）分别为0.99（95%可信区间[CI]， 0.94-1.05）和0.96 （95% CI, 0.93-1.00）。然而，基于有限数量的符合条件的研究，我们未能确定任何剂量-反应关联，鱼和家禽食用量每增加100 g，合并RR分别为0.98 （95% CI, 0.92-1.05）和0.97 （95% CI, 0.88-1.07）。总之，这项荟萃分析表明，食用鱼或家禽与降低癌症总死亡率的风险没有实质性的联系。观察到的与高家禽消费的弱负相关需要在其他大型前瞻性研究中得到验证。
ABSTRACT Observational studies on the association between fish and poultry intake and the risk of total cancer mortality have been reported with mixed results. Thus, we aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through February 1, 2017 to identify relative prospective studies. A random-effects model was used to calculate the summary estimates. We identified fourteen prospective studies involving 2,378,204 participants and 96,712 cancer mortality events. Comparing the highest category of consumption with lowest category, pooled relative risk (RR) of total cancer mortality was 0.99 (95% confidence interval [CI], 0.94–1.05) for fish (10 studies) and 0.96 (95% CI, 0.93–1.00) for poultry (8 studies), respectively. However, we failed to identify any dose–response association based on a limited number of eligible studies, with a pooled RR of 0.98 (95% CI, 0.92–1.05) and 0.97 (95% CI, 0.88–1.07) for each 100 g per day increment in fish and poultry consumption, respectively. In summary, this meta-analysis indicates that consumption of either fish or poultry is not substantially associated with lower risk of total cancer mortality. The observed weak inverse association for high poultry consumption needs to be verified in additional large prospective studies.