EFG1, Everyone's Favorite Gene in Candida albicans: A Comprehensive Literature Review.
EFG1, Everyone's Favorite Gene in Candida albicans: A Comprehensive Literature Review.
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DOI：
10.3389/fcimb.2022.855229
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发表时间：
2022
影响因子：
5.7
通讯作者：
Glazier VE
中科院分区：
文献类型：
--
作者：
Glazier VE
假丝酵母菌是人类微生物群中最常见的真菌共生体之一。虽然假丝酵母菌可以在皮肤和粘膜表面无害地生存，但这些机会性真菌有可能引起皮肤、指甲和粘膜的浅表感染以及危及生命的全身感染。感染的严重程度取决于真菌和宿主因素，包括宿主的免疫状态。念珠菌致病因子的研究。致病性包括粘附素蛋白、降解酶、表型转换和形态发生。转录因子Efg1是形态发生的中心转录调节因子，1997年首次在白色念珠菌中被鉴定。从那时起，EFG1在念珠菌文献中被引用了3000多次，被引用的次数每天都在增加。可以说，EFG1是白色念珠菌中研究最充分的基因之一，从新疗法的发展到白色不透明切换、菌丝形态到免疫学，几乎所有的念珠菌生物学背景都提到了EFG1。在接下来的综述中，我们将综合关于这个被广泛研究的转录因子的研究，并强调几个重要的未回答的问题。
Candida sp. are among the most common fungal commensals found in the human microbiome. Although Candida can be found residing harmlessly on the surface of the skin and mucosal membranes, these opportunistic fungi have the potential to cause superficial skin, nail, and mucus membrane infections as well as life threatening systemic infections. Severity of infection is dependent on both fungal and host factors including the immune status of the host. Virulence factors associated with Candida sp. pathogenicity include adhesin proteins, degradative enzymes, phenotypic switching, and morphogenesis. A central transcriptional regulator of morphogenesis, the transcription factor Efg1 was first characterized in Candida albicans in 1997. Since then, EFG1 has been referenced in the Candida literature over three thousand times, with the number of citations growing daily. Arguably one of the most well studied genes in Candida albicans, EFG1 has been referenced in nearly all contexts of Candida biology from the development of novel therapeutics to white opaque switching, hyphae morphology to immunology. In the review that follows we will synthesize the research that has been performed on this extensively studied transcription factor and highlight several important unanswered questions.