High prevalence of hypothyroidism in patients with primary pulmonary hypertension
High prevalence of hypothyroidism in patients with primary pulmonary hypertension
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DOI：
10.1097/00000441-199911000-00001
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发表时间：
1999-11-01
影响因子：
3.1
通讯作者：
Arroliga, AC
中科院分区：
文献类型：
--
作者：
Curnock, AL;Dweik, RA;Arroliga, AC
目的：描述原发性肺动脉高压（PPH）人群中甲状腺功能减退症的患病率。方法：回顾性记录分析1991年至1997年在三级医疗中心就诊的41例PPH患者。提取的数据包括：既往甲状腺疾病史、甲状腺补充剂摄入情况和甲状腺功能检查。甲状腺功能减退症定义为血清促甲状腺激素（TSH）水平高于5.5 U/L、摄入甲状腺补充剂或血清甲状腺素水平低。结果：在纳入研究的40例PPH患者中（11例男性和29例女性），年龄范围为11至76岁（平均43.5岁）。平均肺动脉压为58.7 mm Hg。33例患者血清TSH水平正常（其中3例补充左旋甲状腺素）; 1例TSH水平低; 5例TSH水平高（范围6.8-9.9 U/L，平均8.4 U/L），1例甲状腺素水平低（T-4 < 1.0 μ g/dL）。40例患者中有9例（22.5%）有甲状腺功能减退症的证据，这远远高于相似年龄范围的一般人群的预期（男性2.8%，女性7.5%）（p = 0.002）。结论：PPH患者甲状腺功能减退症的患病率较高（22.5%）。PPH患者应检查是否存在甲状腺功能减退症。
Purpose: To characterize the prevalence of hypothyroidism in a population with primary pulmonary hypertension (PPH).Methods: Retrospective record review of 41 patients with PPH seen between 1991 and 1997 at a tertiary care center. Data abstracted included: history of previous thyroid disease, intake of thyroid supplement, and thyroid function tests. Hypothyroidism was defined as a serum thyroid stimulating hormone (TSH) level higher than 5.5 U/L, intake of thyroid supplement, or low serum thyroxine level. Results: Of the 40 patients with PPH included in the study (11 men and 29 women), ages ranged from 11 to 76 years (mean 43.5 years). The mean pulmonary artery pressure was 58.7 mm Hg. Thirty-three patients had normal serum TSH levels (3 of whom were on levothyroxine supplement); 1 had low TSH; 5 had high TSH (range, 6.8-9.9 U/L, mean 8.4 U/L), and 1 had low thyroxine (T-4 < 1.0 mu g/dL). Nine of 40 patients (22.5%) had evidence of hypothyroidism, which is much more than expected in the general population of similar age range (2.8% in men, 7.5% in women) (p = .002). Conclusions: The prevalence of hypothyroidism in patients with PPH is high (22.5%). Patients with PPH should be investigated for the possibility of coexisting hypothyroidism.