Decreased Brain Ventricular Volume in Psychiatric Inpatients with Serotonin Reuptake Inhibitor Treatment.
Decreased Brain Ventricular Volume in Psychiatric Inpatients with Serotonin Reuptake Inhibitor Treatment.
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DOI：
10.1177/24705470221111092
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Salas, R
中科院分区：
文献类型：
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作者：
Bolin, P K;Gosnell, S N;Brandel-Ankrapp, K;Srinivasan, N;Castellanos, A;Salas, R
据报道，在一些神经精神疾病和衰老过程中，脑室会增大。人类脑室容量是否会随着时间的推移而通过精神治疗而减少，目前还没有得到很好的研究。这项研究的目的是检查服用5-羟色胺再摄取抑制剂(SRI)的住院患者是否表现出脑室容量的减少。精神科住院患者主要被诊断为抑郁、药物使用、焦虑和人格障碍，他们接受了两次成像会议(时间1和时间2，大约相隔4周)。用Freesurfer对脑体积特征进行量化，用ANOVA分析时间1和时间2的脑室容量差。脑室容量通过除以估计的颅内总体积(ETIV)归一化。临床特征，如抑郁和焦虑水平在时间1、时间1.5(大约相隔2周)和时间2被收集。持续服用SRI(SRI + ，n = 44)的住院患者显示出统计上显著的脑室容量减少，尤其是他们的左右侧脑室容量。他们的第三脑室容量减少接近显著水平(p = .068)。没有服用SRI的住院患者(SRI-，n = 25)显示脑室容量没有统计学上的显著变化。根据脑室容量参数的90%可信区间比较，SRI + 组也表现出与健康对照组相似的脑结构特征，而SRI组治疗后脑室容量仍相对增大。SRI治疗与治疗后脑室体积的减少有关。
Brain ventricles have been reported to be enlarged in several neuropsychiatric disorders and in aging. Whether human cerebral ventricular volume can decrease over time with psychiatric treatment is not well-studied. The aim of this study was to examine whether inpatients taking serotonin reuptake inhibitors (SRI) exhibited reductions in cerebral ventricular volume. Psychiatric inpatients, diagnosed mainly with depression, substance use, anxiety, and personality disorders, underwent two imaging sessions (Time 1 and Time 2, approximately 4 weeks apart). FreeSurfer was used to quantify volumetric features of the brain, and ANOVA was used to analyze ventricular volume differences between Time 1 and Time 2. Inpatients’ brain ventricle volumes were normalized by dividing by estimated total intracranial volume (eTIV). Clinical features such as depression and anxiety levels were collected at Time 1, Time 1.5 (approximately 2 weeks apart), and Time 2. Inpatients consistently taking SRIs (SRI + , n = 44) showed statistically significant reductions of brain ventricular volumes particularly for their left and right lateral ventricular volumes. Reductions in their third ventricular volume were close to significance (p = .068). The inpatients that did not take SRIs (SRI-, n = 25) showed no statistically significant changes in brain ventricular volumes. The SRI + group also exhibited similar brain structural features to the healthy control group based on the 90% confidence interval comparsions on brain ventricular volume parameters, whereas the SRI- group still exhibited relatively enlarged brain ventricular volumes after treatment. SRI treatment was associated with decreased brain ventricle volume over treatment.