THE PATTERN OF INTERSTITIAL TROPHOBLASTIC INVASION OF THE MYOMETRIUM IN EARLY HUMAN-PREGNANCY
THE PATTERN OF INTERSTITIAL TROPHOBLASTIC INVASION OF THE MYOMETRIUM IN EARLY HUMAN-PREGNANCY
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DOI：
10.1016/s0143-4004(81)80027-6
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发表时间：
1981-01-01
期刊：
影响因子：
3.8
通讯作者：
BROSENS, I
中科院分区：
文献类型：
--
作者：
PIJNENBORG, R;BLAND, JM;BROSENS, I
对妊娠8-18周的42例完整子宫切除标本进行研究，发现人胎盘床子宫肌层内存在大量非绒毛浸润性细胞滋养层细胞。定量形态学分析揭示了一种趋势，最大的侵入活动发生在中心，随后，向离心延伸，产生一个环形图案。形态学观察表明，细胞滋养层与子宫肌层组织的紧密混合物一定会影响子宫肌层的机械性能。滋养层产生的局部激素可能会诱导或增强子宫组织中这些和其他对人类胎盘形成至关重要的变化。细胞滋养层侵入子宫肌层似乎仅限于妊娠早期，形态学证据表明，随后，细胞滋养层融合形成多核合胞体滋养层，特征性胎盘床巨细胞。
The human placental bed myometrium, studied in 42 intact hysterectomy specimens ranging from 8-18 wk gestation, is characterized by the presence of large numbers of non-villous invasive cytotrophoblastic cells. Quantitative morphometric analysis reveals a tendency for maximal invasive activity to occur at the center and, subsequently, to extend centrifugally to produce an annular pattern. Morphological observations suggest that the intimate mixture of cytotrophoblast with myometrial tissue must affect the mechanical properties of the myometrium. Local hormone production by trophoblast may induce or enhance these and other changes in uterine tissues that are essential for the establishment of human placentation. Cytotrophoblastic invasion into the myometrium appears to be restricted to the earlier stages of gestation and morphological evidence indicates that, subsequently, clumps of cytotrophoblast fuse to form multinuclear syncytiotrophoblast, the characteristic placental bed giant cells.