Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere.
Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere.
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DOI：
10.1159/000244036
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
J. Towfighi;C. Housman;R. Vannucci;D. Heitjan
中科院分区：
文献类型：
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作者：
J. Towfighi;C. Housman;R. Vannucci;D. Heitjan
用幼年大鼠观察单侧围产期脑缺氧缺血损伤对对侧脑大体发育的影响。8天龄大鼠结扎一侧颈总动脉，37℃低氧1~2 h，3周后处死动物，通过称量大脑半球重量，测量大脑半球横截面积、直径和新皮质厚度，评价脑损伤程度。与对照组相比，损伤侧大脑半球的大小或皮质厚度均无显著差异。结果表明：(1)围产期一侧大脑半球的损伤不会显著改变另一侧大脑半球的大小；(2)对侧大脑半球可作为评估围产期早期缺氧缺血损伤的大脑半球萎缩或梗塞程度的“正常”参考。
The effect of unilateral perinatal cerebral hypoxic-ischemic damage on the gross development of the opposite hemisphere was investigated in immature rats. Eight-day-old rats underwent unilateral common carotid artery ligation followed by exposure to hypoxia (8% oxygen) ranging from 1 to 2 h at 37 degrees C. The animals were sacrificed 3 weeks later, and brain damage was assessed histologically, by weighing the cerebral hemispheres, and by measuring hemispheric cross-sectional area and diameter as well as the thickness of neocortex. There were no significant differences in either the size or cortical thickness of the cerebral hemisphere contralateral to the damaged hemisphere compared to those of controls. The results are comparable to the effect of unilateral perinatal hemispheric decortication and hemispherectomy on the growth of the contralateral hemisphere and suggest that: (1) perinatal damage to one cerebral hemisphere does not significantly alter the size of the other hemisphere, and (2) the contralateral hemisphere may be used as a 'normal' reference in evaluating the extent of atrophy or infarction of a cerebral hemisphere damaged earlier by perinatal hypoxia-ischemia.