VITAMIN D RESISTANT HYPOPHOSPHATAEMIC OSTEOMALACIA: TREATMENT WITH la–HYDROXYVITAMIN D3
VITAMIN D RESISTANT HYPOPHOSPHATAEMIC OSTEOMALACIA: TREATMENT WITH la–HYDROXYVITAMIN D3
复制标题
维生素 D 抵抗性低磷酸盐性骨软化症：用 1α-羟基维生素 D3 治疗
作者：
M. Peacock;P. Heyburn;J. Aaron
本文报道10例维生素D抵抗性低磷性骨软化症。他们有低磷血症，小管对磷酸盐的再吸收减少，钙和磷的吸收不良，近端肌病和髂嵴骨活检时广泛的骨代沟改变。然而，只有部分患者血浆碱性磷酸酶和尿羟脯氨酸升高。大剂量l -羟基维生素D3治疗能迅速治愈肌病，增加钙、磷的吸收和潴留，治愈骨软化。不需要补充磷。
Ten patients with vitamin D resistant hypophosphataemic osteomalacia are described. They had hypophosphataemia with a decreased tubular reabsorption of phosphate, malabsorption of calcium and phosphorus, proximal myopathy and extensive osteomdacic changes on iliac crest bone biopsy. The plasma alkaline phosphatase and urine hydroxyproline, however, were raised in only some of the patients. Treatment with l a–hydroxyvitamin D3 in high doses rapidly cured the myopathy, increased calcium and phosphorus absorption and retention and healed the osteomalacia. Phosphorus supplements were not required.