Asymmetric transfer hydrogenation of aryl ketones catalyzed by salt-free two samarium centers supported by a chiral multidentate alkoxy ligand.
Asymmetric transfer hydrogenation of aryl ketones catalyzed by salt-free two samarium centers supported by a chiral multidentate alkoxy ligand.
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DOI：
10.1002/chin.200515030
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发表时间：
2004-11
期刊：
影响因子：
5.2
通讯作者：
K. Ohno;Yasutaka Kataoka;K. Mashima
中科院分区：
文献类型：
--
作者：
K. Ohno;Yasutaka Kataoka;K. Mashima
[反应：我们合成了一个手性多齿配体（R，R，R，R）-N，N，N '，N'-四（2-羟基-2-苯乙基）-1，3-苯二甲胺[（R）-2]，它可以在相邻位置上负载两个金属离子。用（R）-2的无盐钐镧系配合物催化苯乙酮及其衍生物的不对称氢转移反应，发现两个钐原子与（R）-2的组合是最佳的催化体系，具有较高的对映选择性（ee>99%）。
[reaction: see text] We synthesized a chiral multidentate ligand, (R,R,R,R)-N,N,N',N'-tetra(2-hydroxy-2-phenylethyl)-1,3-xylylene diamine [(R)-2], which can support two metals at adjacent positions. Asymmetric transfer hydrogenation of acetophenone and its derivatives was conducted by using salt-free bimetallic lanthanoid complexes of (R)-2, and the combination of two samarium atoms and (R)-2 was found to be the best catalyst system for asymmetric transfer hydrogenation of aryl ketones in high enantioselectivity (up to >99% ee).