Formal Direct Cross-Coupling of Phenols with Amines
Formal Direct Cross-Coupling of Phenols with Amines
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DOI：
10.1002/anie.201506751
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发表时间：
2015-11-23
影响因子：
16.6
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Chen, Zhengwang;Zeng, Huiying;Li, Chao-Jun
在过去的几十年中，过渡金属催化的芳基卤的胺化反应是形成芳基胺的最有效的方法。酚类化合物被认为是卤代芳烃的理想替代物。一种有效的钯催化的酚类化合物与各种胺和苯胺的形式交叉偶联现已被开发出来。各种取代酚与标准反应条件相容。因此，仲和叔芳基胺可以以中等至优异的产率合成。
The transition-metal-catalyzed amination of aryl halides has been the most powerful method for the formation of aryl amines over the past decades. Phenols are regarded as ideal alternatives to aryl halides as coupling partners in cross-couplings. An efficient palladium-catalyzed formal cross-coupling of phenols with various amines and anilines has now been developed. A variety of substituted phenols were compatible with the standard reaction conditions. Secondary and tertiary aryl amines could thus be synthesized in moderate to excellent yields.