Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages.
Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages.
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DOI：
10.14800/ics.161
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发表时间：
2014-06
影响因子：
--
通讯作者：
M. Cathcart;A. Bhattacharjee
中科院分区：
文献类型：
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作者：
M. Cathcart;A. Bhattacharjee
单核/巨噬细胞是一种多功能细胞，主要参与宿主防御和免疫。Th1细胞因子在单核/巨噬细胞中诱导经典的激活程序，导致促炎的M1巨噬细胞表型，而Th2细胞因子IL-4和IL-13促进单核细胞分化为交替激活的、抗炎的M2巨噬细胞表型。虽然单胺氧化酶A(MAO-A)主要以其在神经系统中的作用而闻名，但最近的几项研究发现，MAO-A是单核/巨噬细胞交替激活的标志物。在这篇简短的综述中，我们探索了调节交替激活的单核/巨噬细胞中MAO-A表达的信号通路/分子。我们进一步讨论了MAO-A对炎症消退的贡献，并确定了控制炎症的潜在治疗靶点。综上所述，这篇综述对MAO-A在单核/巨噬细胞交替激活及其参与炎症反应中的作用提供了更深入的见解。
Monocytes/macrophages are versatile cells centrally involved in host defense and immunity. Th1 cytokines induce a classical activation program in monocytes/macrophages leading to a proinflammatory M1 macrophage phenotype while Th2 cytokines IL-4 and IL-13 promote monocyte differentiation into an alternatively activated, anti-inflammatory M2 macrophage phenotype. Although monoamine oxidase A (MAO-A) is primarily known for its action in the nervous system, several recent studies have identified MAO-A as a signature marker of alternative activation of monocytes/macrophages. In this brief review we explore the signaling pathways/molecules that regulate MAO-A expression in alternatively activated monocytes/macrophages. We further discuss the contribution of MAO-A to the resolution of inflammation and identify potential therapeutic targets for controlling inflammation. Altogether this review provides deeper insight into the role of MAO-A in alternative activation of monocytes/macrophages and their participation in the inflammatory response.