c-kit+ cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair
c-kit+ cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair
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DOI：
10.1038/nm.3888
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发表时间：
2015-08-01
期刊：
影响因子：
82.9
通讯作者：
Zhou, Bin
中科院分区：
文献类型：
--
作者：
Liu, Qiaozhen;Huang, Xiuzhen;Zhou, Bin
了解肺再生过程中驻留干细胞的命运规范具有重要的临床意义。有报道称，c-kit(+)祖细胞存在于人肺内，移植到受损的小鼠肺内可再生上皮样细胞。在这里，我们通过可诱导的遗传谱系追踪来测试c-kit(+)细胞的谱系潜力。我们发现c-kit(+)细胞在动态平衡和修复过程中并不促进肺上皮细胞的生长，而是维持血管内皮细胞的命运。这些发现提醒人们注意c-kit(+)干细胞作为肺上皮祖细胞在肺部疾病治疗中的临床应用。
Unraveling the fate specification of resident stem cells during lung regeneration is of clinical importance. It has been reported that c-kit(+) progenitor cells resident in the human lung regenerate epithelial lineages upon transplantation into injured mouse lung. Here we test the lineage potential of c-kit(+) cells by inducible genetic lineage tracing. We find that c-kit(+) cells do not contribute to lung epithelium during homeostasis and repair, and instead maintain a vascular endothelial cell fate. These findings call attention to the clinical application of c-kit(+) stem cells as lung epithelial progenitors for the treatment of pulmonary disease.