Potential pathways to restore β-cell mass: pluripotent stem cells, reprogramming, and endogenous regeneration.
Potential pathways to restore β-cell mass: pluripotent stem cells, reprogramming, and endogenous regeneration.
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DOI：
10.1007/s11892-011-0218-7
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发表时间：
2011-10
影响因子：
4.2
通讯作者：
Odorico, Jon
中科院分区：
文献类型：
--
作者：
Baiu, Dana;Merriam, Fabiola;Odorico, Jon
关键词：
目前可用于糖尿病患者的β细胞替代疗法，包括胰岛和胰腺移植，在恢复正常葡萄糖代谢方面基本上是成功的，但器官供体的稀缺限制了其更广泛的使用。为了解决这一供应问题，正在寻求实现β细胞群恢复的几种不同策略。这些方法包括从干细胞产生辟田胞及其随后的移植，或再生型方法，如刺激内源性再生机制或诱导非辟田胞重编程为辟田胞。由于这些策略最终会在人体中产生同种异体或同系辟田胞，因此除了替换丢失的辟田胞之外，控制同种异体免疫和/或自身免疫将是极其重要的。我们简要回顾了这三种有前途的β细胞替代或修复策略的最新文献，并指出了影响其转化为治疗人类糖尿病的主要问题。
Currently available β-cell replacement therapies for patients with diabetes, including islet and pancreas transplantation, are largely successful in restoring normal glucose metabolism, but the scarcity of organ donors restricts their more widespread use. To solve this supply problem, several different strategies for achieving β-cell mass restoration are being pursued. These include the generation of β cells from stem cells and their subsequent transplantation, or regeneration-type approaches, such as stimulating endogenous regenerative mechanisms or inducing reprogramming of non-β cells into β cells. Because these strategies would ultimately generate allogeneic or syngeneic β cells in humans, the control of alloimmunity and/or autoimmunity in addition to replacing lost β cells will be of utmost importance. We briefly review the recent literature on these three promising strategies toward β-cell replacement or restoration and point out the major issues impacting their translation to treating human diabetes.
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