Quantitative Analyses of Coupling in Hybrid Zones
Quantitative Analyses of Coupling in Hybrid Zones
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DOI：
10.1101/cshperspect.a041434
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发表时间：
2023-12-01
影响因子：
7.2
通讯作者：
Gompert，Zachariah
中科院分区：
文献类型：
--
作者：
Firneno Jr，Thomas J.;Semenov，Georgy;Gompert，Zachariah
在杂交区，障碍区的选择主要是独立的，还是作为一个整体，取决于耦合系数捕捉到的选择与重组的比率。理论预测，当更多的基因座影响混合适应度时，非耦合系统和耦合系统之间的转换会更尖锐。然而，混合区的耦合程度很少被量化。在这里，我们使用模拟来描述耦合系数和遗传基因座之间的倾斜方差之间的关系。然后，我们重新分析了25个混合区数据集，发现倾斜方差和估计的耦合系数形成了从高方差和弱耦合到低方差和强耦合的光滑连续体。我们的结果与低杂交率和当耦合系数远大于1时基因组范围内对基因流动的强烈障碍是一致的，但也表明随着时间的推移，这一边界可能会以几乎恒定的速度逐渐接近。
In hybrid zones, whether barrier loci experience selection mostly independently or as a unit depends on the ratio of selection to recombination as captured by the coupling coefficient. Theory predicts a sharper transition between an uncoupled and coupled system when more loci affect hybrid fitness. However, the extent of coupling in hybrid zones has rarely been quantified. Here, we use simulations to characterize the relationship between the coupling coefficient and variance in clines across genetic loci. We then reanalyze 25 hybrid zone data sets and find that cline variances and estimated coupling coefficients form a smooth continuum from high variance and weak coupling to low variance and strong coupling. Our results are consistent with low rates of hybridization and a strong genome-wide barrier to gene flow when the coupling coefficient is much greater than 1, but also suggest that this boundary might be approached gradually and at a near constant rate over time.