Pt nanozyme for O2 self-sufficient, tumor-specific oxidative damage and drug resistance reversal
Pt nanozyme for O2 self-sufficient, tumor-specific oxidative damage and drug resistance reversal
复制标题
Pt 纳米酶用于 O-2 自给自足、肿瘤特异性氧化损伤和耐药性逆转
DOI：
10.1039/c9nh00088g
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发表时间：
2019-09-01
影响因子：
9.7
通讯作者：
Han, Heyou
中科院分区：
文献类型：
--
作者：
Ma, Zhaoyu;Wu, Long;Han, Heyou
Herein, an ultrathin Pt nanozyme has been developed. The Pt nanozyme exhibited both oxidase and peroxidase-mimetic properties, leading to relieved hypoxia and specific oxidative damage in tumor cells in a cascade manner. Meanwhile, hydrophilic Pt2+ was released sustainably under tumor acidity. These properties endow the Pt nanozyme with great potential in killing drug resistant tumor cells while not damaging normal cells.
