The calcineurin target, crz1, functions in azole tolerance but is not required for virulence of Candida albicans
The calcineurin target, crz1, functions in azole tolerance but is not required for virulence of Candida albicans
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DOI：
10.1128/iai.72.12.7330-7333.2004
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发表时间：
2004-12-01
影响因子：
3.1
通讯作者：
Heitman, Joseph
中科院分区：
文献类型：
--
作者：
Onyewu, Chiatogu;Wormley, Floyd L. Jr;Heitman, Joseph
在白色念珠菌，钙调磷酸酶是必不可少的毒力和生存期间膜被唑扰乱。Crz1是基于酿酒酵母研究提出的钙调磷酸酶下游靶点。然而，白色念珠菌crz1/crz1和钙调磷酸酶突变体的体外表型不同，并且crz1不是毒力所必需的。
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.