Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring:: A population-based case-control study
Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring:: A population-based case-control study
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DOI：
10.1002/bdra.20480
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Czeizel, Andrew E.
中科院分区：
文献类型：
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作者：
Acs, Nandor;Banhidy, Ferenc;Czeizel, Andrew E.
背景技术背景：尚未研究孕妇急性盆腔炎（APID）与结构性出生缺陷（即其后代的先天性异常（CA））之间的可能联系。方法：对1980年和1996年匈牙利先天性畸形病例对照监测的数据集进行评价。研究结果：22，843例病例中有67例（0.29%）和38，151例对照中有128例（0.34%）的母亲在妊娠第二个月和/或第三个月期间前瞻性地和医学地记录了APID（校正的患病率OR为95%，CI：0.95，0.70-1.29）。然而，在评估的12个CA组中，APID仅与心血管CA的较高风险相关（校正的患病率OR，95% CI：2.6，-1.2-5.4），观察到的母亲APID暴露的11型房间隔缺损病例数超过预期数的4.2倍。结论：APID与心血管CA高风险相关的一个可能解释是APID的高热，但这一信号发现需要确认。
BACKGROUND: The possible association between acute pelvic inflammatory diseases (APID) of pregnant women and structural birth defects, that is, congenital abnormalities (CA) in their offspring, has not been studied. METHODS: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980 and 1996, were evaluated. RESULTS: There were 67 out of 22,843 (0.29%) cases and 128 Out of 38,151 (0.34%) controls with mothers who had prospectively and medically recorded APID during the second and/or third gestational months (adjusted prevalence OR with 95%, CI: 0.95, 0.70-1.29). However, of 12 CA groups evaluated, APID was associated with a higher risk only for cardiovascular CAs (adjusted prevalence OR with 95% CI: 2.6, -1.2-5.4) and the observed number of cases with atrial septal defect, type 11 with maternal APID exposure exceeded 4.2-fold its expected number. CONCLUSIONS: A possible explanation for the association of APID with higher risk for cardiovascular CA is the high fever of APID, but this signal finding needs confirmation.