On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer.
On target cell numbers in radiation-induced H4-RET mediated papillary thyroid cancer.
复制标题
辐射诱导的 H4-RET 介导的乳头状甲状腺癌中的靶细胞数量。
DOI：
10.1007/s004110100108
复制
发表时间：
2001
影响因子：
1.7
通讯作者：
Little,MP
中科院分区：
文献类型：
--
作者：
Radivoyevitch,T;Sachs,RK;Nikiforov,YE;Nikiforova,MN;Little,MP
辐射诱发的人乳头状甲状腺癌（PTC）与涉及遗传位点h4andreton 10染色体的染色体倒位有关。最近的实验数据表明，这些基因座在成人甲状腺细胞中所占的比例非常接近。将双辐射作用的广义公式应用于这一几何距离数据，我们预测了h4还原的辐射剂量响应。预测的dh4 - retm剂量反应具有线性到二次过渡剂量为~ 7 Gy，这表明线性风险外推的有效性，对于h4 - retm介导的辐射诱导的PTC是非常低的剂量。结合原子弹幸存者的数据，预测的dh4 - retdose - response产生PTC靶细胞数量的估计值为~ 106 ~ ~ 107个细胞，即大大少于甲状腺中滤泡细胞的总数。
Radiation-induced human papillary thyroid cancer (PTC) is associated with chromosomal inversions that involve the genetic lociH4andRETon chromosome 10. Recently, experimental data has shown that these loci lie in very close spatial proximity in a high proportion of adult human thyroid cells. Applying the generalized formulation of dual radiation action to thisH4-to-RETgeometric distance data, we predict here the radiation dose-response ofH4-RETinduction. The predictedH4-RETdose-response has a linear-to-quadratic transition dose of ∼7 Gy, suggesting the validity of linear risk extrapolations to very low doses forH4-RETmediated radiation-induced PTC. In conjunction with A-bomb survivor data, the predictedH4-RETdose- response yields estimates of the number of PTC target cells that are of the order of ∼106to ∼107cells, i.e. considerably less than the total number of follicular cells in the thyroid gland.