Vasopressin induces emesis in Suncus murinus
Vasopressin induces emesis in Suncus murinus
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DOI：
10.1254/jjp.89.324
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发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Matsuki, N
中科院分区：
文献类型：
--
作者：
Ikegaya, Y;Matsuki, N
本文报道了家麝鼠Suncus Murinus体内的加压素是一种催产素。静脉或脑室注射后叶加压素会在几分钟内引起呕吐。静脉注射后叶加压素的ED50高达4.67微克/公斤，而脑室注射后叶加压素在小剂量(20 ng/脑)时有效。因此，加压素的催眠靶点可能存在于中枢神经系统。我们建议Suncus作为一种有用的动物来研究加压素介导的呕吐，包括运动病。
This paper reports that vasopressin is emetogenic in the house musk shrew Suncus murinus. Either intravenous or intracerebroventricular administration of vasopressin caused vomiting within a few minutes. The ED50 of intravenous vasopressin was as high as 4.67 mug/kg, whereas intracerebroventricularly injected vasopressin was effective at a low dose of 20 ng/brain. The emetogenic target of vasopressin may therefore be present in the central nervous system. We propose the Suncus as a useful animal for investigation of vasopressin-mediated emesis, including motion sickness.