Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
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DOI：
10.1002/eji.201344127
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发表时间：
2014-03
影响因子：
5.4
通讯作者：
Fitzgerald KA
中科院分区：
文献类型：
--
作者：
Bhat N;Fitzgerald KA
哺乳动物细胞细胞质中DNA的存在被认为是一个危险信号，提醒宿主微生物感染的存在。在对细胞质DNA检测的反应中，免疫系统产生程序性反应，包括抗病毒基因（如I型干扰素）的转录和炎症细胞因子（如白细胞介素(IL)-1β）的产生。最近发现的cGAS-cGAMP第二信使通路以及IFI16和其他传感器共同为细胞质DNA感应背后的分子基础提供了重要的见解。从这些重要发现中获得的见解可以揭示了解宿主免疫的新途径，改进疫苗佐剂，并允许开发与DNA异常感知相关的炎症性疾病的新治疗方法。
The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response to the detection of cytoplasmic DNA, the immune system mounts a programmed response that involves the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines such as interleukin (IL)-1β. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. The insights obtained from these important discoveries could unveil new avenues to understand host-immunity, improve vaccine adjuvancy and allow development of new treatments for inflammatory diseases associated with abberrant sensing of DNA.