Is Engagement in Intellectual and Social Leisure Activities Protective Against Dementia Risk? Evidence from the English Longitudinal Study of Ageing.
Is Engagement in Intellectual and Social Leisure Activities Protective Against Dementia Risk? Evidence from the English Longitudinal Study of Ageing.
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DOI：
10.3233/jad-200952
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Cadar D
中科院分区：
文献类型：
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作者：
Almeida-Meza P;Steptoe A;Cadar D
研究表明，精神刺激活动和社交生活方式可能会降低患痴呆症的风险；然而，目前还不清楚哪些活动更有益。我们调查了智力和社交休闲活动与痴呆症发病率的关系，并探索了性别和婚姻状况在这些联系中的调节作用。样本包括8030名来自英国老龄化纵向研究的50岁以上的参与者，他们在第一波(2002-2003)、第三波(2006-2007)或第四波(2008-2009年)加入。研究期结束时为第八波(2016-2017)。次级分布风险模型调查了在考虑死亡风险的同时，按智力和社交领域分组的休闲活动与痴呆症的关系。随后对个人休闲活动进行了分析。在长达15年的研究期间，412名参与者患上了痴呆症，2192人死亡。我们发现，增加智力活动领域的参与度与痴呆症发病率的降低有关(自发性高血压病0.85，95%可信区间0.76-0.96p = 0.007)，与已婚个人的死亡风险无关，但在单身、离婚或丧偶的人中则没有。对每项休闲活动的个体分析显示，女性(SHR 0.65，95%CI 0.49-0.84，p = 0.001)、男性使用手机(SHR 0.61，95%CI 0.45-0.84，p = 0.002)和已婚个人爱好(SHR 0.70，95%CI 0.51-0.95，p = 0.02)与阅读报纸(SHR 0.65，95%CI 0.49-0.84，p = 0.02)独立相关。我们发现，在具有代表性的英国成年人中，智力休闲活动有助于降低痴呆症风险，这表明有干预机会。
Studies have suggested that mentally stimulating activities and socially engaged lifestyles may reduce dementia risk; however, it is unclear which activities are more beneficial. We investigated intellectual and social leisure activities in relation to dementia incidence and explored the modifying role of sex and marital status in these associations. The sample was comprised of 8,030 participants aged 50+ from the English Longitudinal Study of Ageing, who joined at wave 1 (2002-2003), or waves 3 (2006-2007), or 4 (2008-2009). The end of the study period was wave 8 (2016-2017). Subdistribution hazard models investigated the role of leisure activities grouped into intellectual and social domains in relation to dementia while accounting for the risk of death. Subsequent analyses were conducted with individual leisure activities. During the study period of up to 15 years, 412 participants developed dementia, and 2,192 died. We found that increased engagement in the intellectual activities’ domain was associated with a decreased dementia incidence (SHR 0.85, 95% CI 0.76–0.96, p = 0.007), independent of the risk of death in married individuals, but not in those who were single, divorced, or widowed. Individual analyses for each leisure activity showed independent associations for reading newspapers in females (SHR 0.65, 95% CI 0.49–0.84, p = 0.001), mobile phone usage in males (SHR 0.61, 95% CI 0.45–0.84, p = 0.002), and having hobbies for married individuals (SHR 0.70, 95% CI 0.51–0.95, p = 0.02). We found that intellectual leisure activities contribute to lower dementia risk in a representative population of English adults, suggesting intervention opportunities.