Effect of Obesity and Overweight on Left Ventricular Diastolic Function A Community-Based Study in an Elderly Cohort
Effect of Obesity and Overweight on Left Ventricular Diastolic Function A Community-Based Study in an Elderly Cohort
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DOI：
10.1016/j.jacc.2010.10.042
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发表时间：
2011-03-22
影响因子：
24
通讯作者：
Di Tullio, Marco R.
中科院分区：
文献类型：
--
作者：
Russo, Cesare;Jin, Zhezhen;Di Tullio, Marco R.
目的 本研究的目的是评估体型增加对左心室 (LV) 舒张功能的独立影响。背景 肥胖和超重的人发生心力衰竭的风险增加。左心室舒张功能障碍是一种与未来心力衰竭相关的无症状病症。目前尚不清楚肥胖和超重是否与左室舒张功能障碍独立相关。方法通过传统和组织多普勒成像对 CABL（心血管异常和脑病变）研究的 950 名参与者进行左室舒张功能评估。测量二尖瓣舒张早期峰值流速（E）、二尖瓣舒张晚期流速（A）和舒张早期二尖瓣环流速（E'），并计算E/A和E/E'。研究样本分为 3 组：正常体重（体重指数 [BMI] = 30 kg/m(2)）。结果 在多变量分析中，BMI 与较高的 E、A 和 E/E'（左室充盈压指标）独立相关（所有 p
Objectives The purpose of this study was to assess the independent effect of increased body size on left ventricular (LV) diastolic function.Background Obese and overweight persons are at increased risk of heart failure. Left ventricular diastolic dysfunction is an asymptomatic condition associated with future heart failure. It is unclear whether obesity and overweight are independently associated with LV diastolic dysfunction.Methods The LV diastolic function was evaluated in 950 participants from the CABL (Cardiovascular Abnormalities and Brain Lesions) study by traditional and tissue Doppler imaging. Peak early transmitral diastolic flow velocity (E), late transmitral diastolic flow velocity (A), and early diastolic mitral annulus velocity (E') were measured, and E/A and E/E' were calculated. The study sample was divided into 3 groups: normal weight (body mass index [BMI] = 30 kg/m(2)).Results In multivariate analyses, BMI was independently associated with higher E, A, and E/E', an indicator of LV filling pressure (all p