Concussion-induced retrograde amnesia in rats.
Concussion-induced retrograde amnesia in rats.
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脑震荡引起的大鼠逆行性遗忘症。
DOI：
10.1016/0031-9384(95)00019-f
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发表时间：
1995
影响因子：
2.9
通讯作者：
Riccio,DC
中科院分区：
文献类型：
--
作者：
Zhou,Y;Riccio,DC
通过三个实验研究大鼠脑震荡所致逆行性遗忘的特点。在实验1中，在单次惩罚试验中，大鼠在训练后不久受到实验性脑震荡，在48小时后的记忆测试中表现出严重的遗忘。在第二个实验中，在训练后6小时内脑震荡的大鼠表现出严重的RA，而在训练后1天至5天内脑震荡的大鼠表现出逐渐减弱的遗忘。在实验3中，一组失忆症动物接受测试前非偶然足部电击作为提醒治疗。这个预试提示显著地增加了穿越延迟，从而表明减少了脑震荡引起的记忆缺陷。实验结果表明，实验性脑震荡是诱导大鼠逆行性记忆丧失的有效方法；脑震荡引起的类风湿性关节炎是有时间依赖性的；并且脑震荡诱发的RA可以通过测试前提示得到缓解，这表明脑震荡诱发RA的潜在机制更可能是检索缺陷而不是巩固失败。
Three experiments were conducted to investigate the characteristics of retrograde amnesia (RA) induced by concussion in rats. In Experiment 1, rats receiving experimental concussion shortly after training in a single punishment trial exhibited severe forgetting on a retention test 48 h later. In the second experiment, rats receiving a concussion within 6 h after training showed severe RA, while those receiving concussion one day to five days after training exhibited progressively weaker amnesia. In Experiment 3, amnesic animals in one group received pretest noncontingent foot shock as a reminder treatment. This pretest cue significantly increased the cross-through latency, thus indicating a reduction in the memory deficit resulting from concussion. These results suggest that experimental concussion can be an effective method to induce retrograde memory loss in rats; that the RA caused by concussion is time-dependent; and that concussion-induced RA can be alleviated by a pretest cue,indicating that the underlying mechanism of concussion-induced RA is more likely to be a retrieval deficit than a consolidation failure.