Functioning ovarian tumors with peripheral steroid cell proliferation: a report of twenty-four cases.
Functioning ovarian tumors with peripheral steroid cell proliferation: a report of twenty-four cases.
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伴有外周类固醇细胞增殖的功能性卵巢肿瘤：二十四例报告。
DOI：
10.1097/00004347-198612000-00004
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Scully
中科院分区：
文献类型：
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作者：
J. Rutgers;R. Scully
本文介绍了 24 例具有功能性基质的罕见卵巢肿瘤病例，其中产生类固醇激素的细胞带位于肿瘤附近。细胞类型为间质叶黄素细胞型14例，间质Leydig细胞型2例，门细胞型8例。外周叶黄素细胞肿瘤中，11例为单胚层畸胎瘤，其中8例为卵巢甲状腺肿，2例为甲状腺肿，1例为小梁类癌。该组中的其他三个肿瘤是皮样囊肿、含有合体滋养层细胞的无性细胞瘤和转移性类癌。具有外周间质间质细胞的肿瘤是卵巢甲状腺肿和甲状腺肿类癌。具有外周门细胞的肿瘤中，三个是粘液性囊腺瘤，四个是可能起源于视网膜的囊肿，八个是皮样囊肿。患者年龄范围为13-82岁（平均58岁）。百分之八十的患者已绝经；其中一个怀孕了。 42% 的患者有雄激素表现，29% 有雌激素亢进的证据，1 名 (4%) 有黄体酮过量的证据。 29% 的病例没有荷尔蒙失衡的临床证据。那些具有外周间质细胞或门细胞的肿瘤在超过一半的病例中伴有雄激素表现，而那些具有外周叶黄素细胞的肿瘤与雌激素变化的相关性略高于与雄激素变化的相关性。通过免疫过氧化物酶技术，在 17 例病例中的 4 例中，在一些肿瘤细胞中证实了人绒毛膜促性腺激素及其 β 亚基。具有外周类固醇激素产生细胞的卵巢肿瘤应与具有功能性基质的典型卵巢肿瘤区分开来，后者含有分散在其基质中的叶黄素细胞。
Twenty-four cases of an unusual type of ovarian tumor with functioning stroma in which bands of steroid-hormone-producing cells were located adjacent to the tumor are presented. The cells were of stromal lutein cell type in 14 cases, stromal Leydig cell type in two cases, and hilus cell type in eight cases. Of the tumors with peripheral lutein cells, 11 were monodermal teratomas, including eight examples of struma ovarii, two strumal carcinoids, and one trabecular carcinoid; the other three tumors in this group were a dermoid cyst, a dysgerminoma containing syncytiotrophoblast cells, and a metastatic carcinoid. The tumors with peripheral stromal Leydig cells were a struma ovarii and a strumal carcinoid. Three of the tumors with peripheral hilus cells were mucinous cystadenomas, four were cysts of probable rete origin, and the eight was a dermoid cyst. The patients' ages ranged from 13-82 (average 58) years. Eighty percent of the patients were postmenopausal; one was pregnant. Forty-two percent of the patients had androgenic manifestations, 29% had evidence of hyperestrinism, and one (4%) had evidence of progesterone excess. In 29% of the cases there was no clinical evidence of hormonal imbalance. Those tumors with peripheral stromal Leydig cells or hilus cells were accompanied by androgenic manifestations in over one-half the cases, and those tumors with peripheral lutein cells had a slightly higher association with estrogenic rather than androgenic changes. Human chorionic gonadotropin and its beta subunit were demonstrated by the immunoperoxidase technique in some neoplastic cells in 4 of the 17 cases in which it was performed. Ovarian tumors with peripheral steroid-hormone-producing cells should be distinguished from the typical ovarian tumor with functioning stroma, which contains lutein cells scattered throughout its stroma.