The increasing incidence of foetal echogenic congenital lung malformations: an observational study
The increasing incidence of foetal echogenic congenital lung malformations: an observational study
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DOI：
10.1002/pd.4507
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发表时间：
2015-02-01
影响因子：
3
通讯作者：
Howe, David T.
中科院分区：
文献类型：
--
作者：
Stocker, Linden J.;Wellesley, Diana G.;Howe, David T.
目的调查我国近19年来先天性肺畸形的发生率。先天性肺畸形（CLM）是一组异质性的肺异常。产前诊断对胎儿和新生儿的管理是重要的，但没有研究检查是否报道这种异常的发生率是恒定的。方法对1994-2012年威塞克斯产前检测异常（WANDA）登记的病例进行回顾性横断面研究。结果524372例活产和死产中检出CLM 133例。除了7个以外，其余都是通过产前超声波确定的。在早期登记期间（1994-1998年），CLM的平均发病率为每10000例分娩1.27例。到最近4年（2008-2012年），这一数字已上升到每1万名新生儿中有4.15人死亡，在此期间不断增加。结论1994-2012年韦塞克斯地区产前检测到的CLM增加了3倍以上。与产前检测膈疝的比较表明，这是一个真正的发病率上升，而不是人为的增加，由于提高了超声分辨率和操作人员的经验，增加了产前识别。这些结果对胎儿医学、新生儿学和儿科外科服务的从业人员具有临床和成本意义。(c) 2014 John Wiley & Sons, Ltd。
ObjectivesThe aim of this study was to investigate the incidence of congenital lung malformations over the past 19years. Congenital lung malformations (CLM) are a heterogeneous group of lung abnormalities. The antenatal diagnosis is important for foetal and neonatal management but there have been no studies examining whether the reported incidence of this abnormality is constant.MethodsA retrospective cross-sectional study of cases identified from the Wessex Antenatally Detected Anomalies (WANDA) register 1994-2012.ResultsOne hundred and thirty-three cases of CLM in 524 372 live and stillbirths were identified. All but seven were identified on antenatal ultrasound. During the early registry (1994-1998) the average incidence of CLM was 1.27 per 10000 births. By the last 4years (2008-2012) this had risen to 4.15 per 10000 births, with a progressive increase during the intervening years.ConclusionThere was over a three-fold increase in the antenatally detected CLM in the Wessex region 1994-2012. Comparison with the antenatal detection of diaphragmatic hernia suggests that this is a true rise in incidence rather than an artefactual increase due to increased antenatal recognition secondary to improved ultrasound resolution and operator experience. These results have clinical and cost implications for practitioners of foetal medicine, neonatology and paediatric surgery services. (c) 2014 John Wiley & Sons, Ltd.