Pathogenesis of influenza A (H5N1) virus infection in a primate model
Pathogenesis of influenza A (H5N1) virus infection in a primate model
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DOI：
10.1128/jvi.75.14.6687-6691.2001
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发表时间：
2001-07-01
影响因子：
5.4
通讯作者：
Osterhaus, ADME
中科院分区：
文献类型：
--
作者：
Rimmelzwaan, GF;Kuiken, T;Osterhaus, ADME
感染A/Hong Kong/156/97(H5N1)流感病毒的食蟹猴出现急性呼吸窘迫综合症和发烧，并伴有坏死性间质性肺炎。逆转录-聚合酶链式反应、病毒分离和免疫组织化学检测表明，呼吸道是病毒的主要靶点。
Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.