Osteonectin-expressing cells in human stomach cancer and their possible clinical significance
Osteonectin-expressing cells in human stomach cancer and their possible clinical significance
复制标题
DOI：
10.1016/s0304-3835(02)00191-x
复制
发表时间：
2002-10-08
期刊：
影响因子：
9.7
通讯作者：
Furihata, C
中科院分区：
文献类型：
--
作者：
Maeng, HY;Song, SB;Furihata, C
本文应用免疫组化和分子生物学方法，对31例分化型胃腺癌、8例未分化型胃腺癌和19例非癌组织中骨粘连蛋白的表达进行了研究。在90%的分化腺癌和63%的未分化腺癌以及26%的非癌胃组织的间质中观察到骨连接素-mAb染色的细胞。竞争性逆转录聚合酶链反应结果与免疫组化数据基本一致。本研究结果表明，骨粘连蛋白是高表达的反应性间质与浸润性分化腺癌，它可能作为一个有用的临床诊断标志物胃癌。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The clinical significance of osteonectin in human stomach cancer was examined immunohistochemically and molecular biologically in 31 differentiated and eight undifferentiated stomach adenocarcinomas and 19 non-cancer stomach tissues. Osteonectin-mAb-stained cells were observed in stroma of 90% differentiated and 63% undifferentiated adenocarcinomas, and of 26% non-cancer stomach tissues. Competitive reverse transcriptase polymerase chain reaction results generally coincided with immunohistochemical data. The present results suggest that osteonectin is highly expressed in reactive stroma associated with invasive differentiated adenocarcinomas and that it may serve as a useful clinical diagnostic marker for stomach cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.