A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge
A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge
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DOI：
10.1016/j.chom.2019.08.014
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发表时间：
2019-09-11
影响因子：
30.3
通讯作者：
Huang, Ying
中科院分区：
文献类型：
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作者：
Pegu, Amarendra;Borate, Bhavesh;Huang, Ying
被动施用针对 HIV-1 包膜糖蛋白 (Env) 的广泛中和抗体 (bNAb) 已被证明可以保护非人灵长类动物 (NHP) 免受嵌合猿-人类免疫缺陷病毒 (SHIV) 感染。根据使用单一 bNAb 的多项非人灵长类 SHIV 攻击研究的数据，我们进行了一项荟萃分析，以检查针对攻击病毒的预测血清 50% 中和滴度 (ID50) 与感染结果之间的关系。在调整 bNAb 表位和攻击病毒的逻辑模型中，血清 ID50 对感染风险具有非常显着的影响 (p < 0.001)。实现 50%、75% 和 95% 保护的估计 ID50 分别为 91（95% 置信区间 [CI]：55、153）、219（117、410）和 685（319、1471）。该分析表明，针对相关病毒的血清中和滴度是保护的关键参数，并且通过单一 bNAb 获得的保护可能需要在暴露时进行大量中和。
Passively administered broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have been shown to protect non-human primates (NHPs) against chimeric simian-human immunodeficiency virus (SHIV) infection. With data from multiple non-human primate SHIV challenge studies that used single bNAbs, we conducted a meta-analysis to examine the relationship between predicted serum 50% neutralization titer (ID50) against the challenge virus and infection outcome. In a logistic model that adjusts for bNAb epitopes and challenge viruses, serum ID50 had a highly significant effect on infection risk (p < 0.001). The estimated ID50 to achieve 50%, 75%, and 95% protection was 91 (95% confidence interval [CI]: 55, 153), 219 (117, 410), and 685 (319, 1471), respectively. This analysis indicates that serum neutralizing titer against the relevant virus is a key parameter of protection and that protection from acquisition by a single bNAb might require substantial levels of neutralization at the time of exposure.