Diverse application of MRI for mouse phenotyping.
Diverse application of MRI for mouse phenotyping.
复制标题
MRI 在小鼠表型分析中的多样化应用。
DOI：
10.1002/bdr2.1051
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发表时间：
2017
影响因子：
2.1
通讯作者：
Lo,CeciliaW
中科院分区：
文献类型：
--
作者：
Wu,YijenL;Lo,CeciliaW
人类疾病的小动物模型，特别是小鼠模型，正在成为生物医学研究不可或缺的工具。动物模型的研究为疾病的病因学提供了重要的见解，并加速了治疗策略的发展。详细的表型表征是必不可少的，无论是对这种动物模型的发展和疾病发病机理的机制研究和测试实验治疗的功效。MRI是一种多功能、无创的成像方式，具有出色的穿透深度、组织覆盖范围和软组织对比度。MRI是一种多模态成像方式，加上经过验证的成像方案和良好造影剂的可用性，非常适合对突变小鼠模型进行表型分型。在这里，我们描述了MRI的表型结构性出生缺陷，涉及大脑，心脏和肾脏在小鼠中的应用。MRI的多功能性及其易用性非常适合于满足功能基因组学时代对小鼠表型分析的快速增长的需求。出生缺陷研究109：758-770，2017年。© 2017威利期刊公司.
Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essential, both for the development of such animal models and mechanistic studies into disease pathogenesis and testing the efficacy of experimental therapeutics. MRI is a versatile and noninvasive imaging modality with excellent penetration depth, tissue coverage, and soft tissue contrast. MRI, being a multi‐modal imaging modality, together with proven imaging protocols and availability of good contrast agents, is ideally suited for phenotyping mutant mouse models. Here we describe the applications of MRI for phenotyping structural birth defects involving the brain, heart, and kidney in mice. The versatility of MRI and its ease of use are well suited to meet the rapidly increasing demands for mouse phenotyping in the coming age of functional genomics. Birth Defects Research 109:758–770, 2017. © 2017 Wiley Periodicals, Inc.