Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology
Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology
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DOI：
10.1186/s12894-015-0106-6
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发表时间：
2015-11-04
期刊：
影响因子：
2
通讯作者：
Malykhina, Anna P.
中科院分区：
文献类型：
--
作者：
Hypolite, Joseph A.;Malykhina, Anna P.
背景：蛋白激酶C（PKC）在包括膀胱在内的许多组织和器官中表达，然而，其在膀胱生理学和病理生理学中的作用仍在不断发展。本综述的目的是评估 PKC 在生理和病理生理条件下参与调节逼尿肌收缩力、膀胱壁肌张力、自发收缩活动和膀胱功能的现有证据。方法：这是对已发表文献的非系统综述，总结了不同生理和病理生理条件下 PKC 信号在膀胱中的作用的现有动物和人类数据。进行了广泛的 PubMed 搜索，包括以下关键词的组合：“膀胱”、“PKC”、“逼尿肌收缩性”、“膀胱平滑肌”、“逼尿肌松弛”、“峰值力”、“逼尿肌活动不足”、“部分膀胱出口梗阻”、“电压门控通道”、“膀胱神经”、“PKC 抑制剂”、“PKC 激活剂”。对检索到的文章进行了单独筛选，以确定与本综述主题的相关性，选择了 91 篇引用并将其纳入数据分析。讨论：膀胱功能包括在低膀胱内压力下储存尿液的能力，随后由于快速阶段性收缩而释放膀胱内容物，这种收缩持续足够长的时间以确保完全排空。这篇综述总结了有关 PKC 对收缩性、生理性排尿的潜在贡献以及涉及排尿周期的储存和排空阶段以及排尿功能障碍的控制的相关信号机制的当前概念。先前的研究仅将 PKC 激活与平滑肌收缩峰值力的产生和下尿路最大力的产生的增加联系起来。最近的数据表明，PKC 对膀胱功能具有更广泛的影响，包括调节逼尿肌的储存、排空、兴奋性和膀胱神经支配。总结：在这篇综述中，我们评估了膀胱中 PKC 信号传导的外周和局部调节机制，以及它们在生理和病理生理条件下对排尿周期不同阶段的影响。
Background: Protein kinase C (PKC) is expressed in many tissues and organs including the urinary bladder, however, its role in bladder physiology and pathophysiology is still evolving. The aim of this review was to evaluate available evidence on the involvement of PKC in regulation of detrusor contractility, muscle tone of the bladder wall, spontaneous contractile activity and bladder function under physiological and pathophysiological conditions.Methods: This is a non-systematic review of the published literature which summarizes the available animal and human data on the role of PKC signaling in the urinary bladder under different physiological and pathophysiological conditions. A wide PubMed search was performed including the combination of the following keywords: "urinary bladder", "PKC", "detrusor contractility", "bladder smooth muscle", "detrusor relaxation", "peak force", "detrusor underactivity", "partial bladder outlet obstruction", "voltage-gated channels", "bladder nerves", "PKC inhibitors", "PKC activators". Retrieved articles were individually screened for the relevance to the topic of this review with 91 citations being selected and included in the data analysis.Discussion: Urinary bladder function includes the ability to store urine at low intravesical pressure followed by a subsequent release of bladder contents due to a rapid phasic contraction that is maintained long enough to ensure complete emptying. This review summarizes the current concepts regarding the potential contribution of PKC to contractility, physiological voiding, and related signaling mechanisms involved in the control of both the storage and emptying phases of the micturition cycle, and in dysfunctional voiding. Previous studies linked PKC activation exclusively with an increase in generation of the peak force of smooth muscle contraction, and maximum force generation in the lower urinary tract. More recent data suggests that PKC presents a broader range of effects on urinary bladder function including regulation of storage, emptying, excitability of the detrusor, and bladder innervation.Summary: In this review, we evaluated the mechanisms of peripheral and local regulation of PKC signaling in the urinary bladder, and their impact on different phases of the micturition cycle under physiological and pathophysiological conditions.