Transgenerational inheritance of ethanol preference is caused by maternal NPF repression
Transgenerational inheritance of ethanol preference is caused by maternal NPF repression
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DOI：
10.7554/elife.45391
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发表时间：
2019-07-09
期刊：
影响因子：
7.7
通讯作者：
Bosco, Giovanni
中科院分区：
文献类型：
--
作者：
Bozler, Julianna;Kacsoh, Balint Z.;Bosco, Giovanni
对环境条件的快速甚至预期适应可以为生物体提供决定性的适应优势。对反复出现的情况的记忆也可能使后代受益;然而，神经元编码的行为并不被认为是跨代遗传的。我们测试了环境引发的修改可能允许父母经历的“记忆”被继承的可能性。在黑腹果蝇中，暴露于捕食性黄蜂导致对富含乙醇食物的易感性遗传了五代。神经肽-F（NPF）的抑制激活跨代乙醇偏好所需的种系半胱天冬酶。此外，遗传的低NPF表达的特定区域的F-1的大脑是必要的，这种食物偏好的传输：一个母系衍生的NPF基因座是必要的这种现象，暗示了母系的NPF抑制的表观遗传机制。鉴于NPF及其哺乳动物NPY同系物在药物和酒精障碍中的保守信号功能，这些观察结果提出了人类中NPY相关跨代效应的有趣可能性。
Rapid or even anticipatory adaptation to environmental conditions can provide a decisive fitness advantage to an organism. The memory of recurring conditions could also benefit future generations; however, neuronally-encoded behavior isn't thought to be inherited across generations. We tested the possibility that environmentally triggered modifications could allow 'memory' of parental experiences to be inherited. In Drosophila melanogaster, exposure to predatory wasps leads to inheritance of a predisposition for ethanol-rich food for five generations. Inhibition of Neuropeptide-F (NPF) activates germline caspases required for transgenerational ethanol preference. Further, inheritance of low NPF expression in specific regions of F-1 brains is required for the transmission of this food preference: a maternally derived NPF locus is necessary for this phenomenon, implicating a maternal epigenetic mechanism of NPF-repression. Given the conserved signaling functions of NPF and its mammalian NPY homolog in drug and alcohol disorders, these observations raise the intriguing possibility of NPY-related transgenerational effects in humans.