Sensory discharges in single cutaneous nerve fibres.
Sensory discharges in single cutaneous nerve fibres.
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DOI：
10.1113/jphysiol.1931.sp002781
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发表时间：
1931-08-01
影响因子：
5.5
通讯作者：
Hoagland, H
中科院分区：
文献类型：
--
作者：
Adrian, ED;Cattell, M;Hoagland, H
在蛙背皮神经中，可以研究来自触觉感受器的单个神经纤维的脉冲放电。这些神经中有许多包含一根纤维，它在脊髓附近分裂，并将分支分成两个神经干。当由一个分支提供的皮肤接受区受到刺激时，反反脉冲就会传递到另一个分支，并在它所在的神经干中被记录下来。背皮神经的一根纤维所支配的皮肤面积从4平方到100平方不等。嗯，但在给定的制剂中，尽管青蛙体内发生了各种生理变化，但这个区域保持不变。由不同的纤维提供的区域有相当大的重叠，但没有证据表明有几个纤维共同的外围网络。触觉末端适应得非常快：只有在皮肤的实际运动中才会产生冲动，而非常缓慢的运动可能无法激发。由间歇性空气爆炸引起的皮肤振动产生长时间和高频率的放电。单个神经纤维的放电频率可能高达每秒200-300次，这接近纤维所能承载的最大频率。以前提出的感觉末梢比它们的神经纤维有更长的绝对不应期的观点是不正确的。在一个完整或退化的青蛙中，高频中断的空气刺激不会引起疼痛反应，尽管最大的放电会在感觉纤维中建立起来。因此，当放电频率很高时，对这种形式的刺激作出反应的末梢不会产生疼痛。所讨论的末端位于表皮中，因为在表皮被刮掉之后，就不能再获得分泌物了。这种治疗设置了一个缓慢脉冲的持续放电，与皮肤上的酸产生的脉冲没有区别。
The impulse discharges in single nerve fibers from the tactile receptors can be studied in the dorsal cutaneous nerves of the frog. Many of these nerves contain a single fiber which has divided near the cord and sent branches into 2 nerve trunks. On stimulation of the receptive skin area supplied by one branch, antidromic impulses pass down the other branch and can be recorded in the nerve trunk in which it runs. The skin area supplied by a single fiber of the dorsal cutaneous nerve varies from 4 to 100 sq. mm., but in a given preparation the area remains constant despite various physiological changes induced in the frog. There is considerable overlapping of the areas supplied by different fibers, but no evidence of a peripheral network common to several fibers. The tactile endings become adapted very rapidly: impulses are set up only during the actual movement of the skin, and a very slow movement may fail to excite. Skin vibration caused by an intermittent air blast produces discharges of long duration and high frequency. The frequency of discharge in a single nerve fiber may be as high as 200-300 a sec. This approaches the maximum frequency which the fiber can carry. The view, put forward previously, that the sensory endings have a longer absolute refractory period than their nerve fibers is incorrect. Stimulation with an air blast interrupted at a high frequency does not give rise to pain reactions in an intact or decererate frog in spite of the maximal discharge which would be set up in the sensory fibers. Thus the endings responding to this form of stimulation do not produce pain when the discharge frequency is very high. The endings in question are situated in the epidermis, for the discharge can no longer be obtained after this has been scraped away. This treatment sets up a continued discharge of slow impulses indistinguishable from those produced by acid on the skin.